EIF2B2 protein (Dromaius novaehollandiae) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

EIF2B2

Eukaryotic translation initiation factor 2B subunit beta. (388 aa)

Predicted Functional Partners:

EIF2B4

0.999

EIF2B5

0.999

EIF2S1

0.999

EIF2B3

0.999

EIF2B1

0.999

EIF2S3

0.997

EIF2S2

0.995

EEFSEC

0.909

LTV1

0.863

RRAGB

0.857

Your Current Organism:

Dromaius novaehollandiae

NCBI taxonomy Id: 8790
Other names: D. novaehollandiae, Dromaius novae-hollandiae, emu

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EEFSEC	EIF2B1	ENSDNVP00000004482	ENSDNVP00000022809	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2B subunit alpha.	0.909
EEFSEC	EIF2B2	ENSDNVP00000004482	ENSDNVP00000002932	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2B subunit beta.	0.909
EEFSEC	EIF2B3	ENSDNVP00000004482	ENSDNVP00000014188	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2B subunit gamma.	0.870
EEFSEC	EIF2B4	ENSDNVP00000004482	ENSDNVP00000002268	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2B subunit delta.	0.909
EEFSEC	EIF2B5	ENSDNVP00000004482	ENSDNVP00000002849	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2B subunit epsilon.	0.870
EEFSEC	EIF2S1	ENSDNVP00000004482	ENSDNVP00000003186	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2 subunit alpha.	0.992
EEFSEC	EIF2S2	ENSDNVP00000004482	ENSDNVP00000016555	Eukaryotic elongation factor, selenocysteine-tRNA specific.	Eukaryotic translation initiation factor 2 subunit beta.	0.995
EIF2B1	EEFSEC	ENSDNVP00000022809	ENSDNVP00000004482	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic elongation factor, selenocysteine-tRNA specific.	0.909
EIF2B1	EIF2B2	ENSDNVP00000022809	ENSDNVP00000002932	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2B subunit beta.	0.999
EIF2B1	EIF2B3	ENSDNVP00000022809	ENSDNVP00000014188	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2B subunit gamma.	0.999
EIF2B1	EIF2B4	ENSDNVP00000022809	ENSDNVP00000002268	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2B subunit delta.	0.999
EIF2B1	EIF2B5	ENSDNVP00000022809	ENSDNVP00000002849	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2B subunit epsilon.	0.999
EIF2B1	EIF2S1	ENSDNVP00000022809	ENSDNVP00000003186	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2 subunit alpha.	0.999
EIF2B1	EIF2S2	ENSDNVP00000022809	ENSDNVP00000016555	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2 subunit beta.	0.996
EIF2B1	EIF2S3	ENSDNVP00000022809	ENSDNVP00000009289	Eukaryotic translation initiation factor 2B subunit alpha.	Eukaryotic translation initiation factor 2 subunit gamma.	0.996
EIF2B1	LTV1	ENSDNVP00000022809	ENSDNVP00000011717	Eukaryotic translation initiation factor 2B subunit alpha.	LTV1 ribosome biogenesis factor.	0.913
EIF2B2	EEFSEC	ENSDNVP00000002932	ENSDNVP00000004482	Eukaryotic translation initiation factor 2B subunit beta.	Eukaryotic elongation factor, selenocysteine-tRNA specific.	0.909
EIF2B2	EIF2B1	ENSDNVP00000002932	ENSDNVP00000022809	Eukaryotic translation initiation factor 2B subunit beta.	Eukaryotic translation initiation factor 2B subunit alpha.	0.999
EIF2B2	EIF2B3	ENSDNVP00000002932	ENSDNVP00000014188	Eukaryotic translation initiation factor 2B subunit beta.	Eukaryotic translation initiation factor 2B subunit gamma.	0.999
EIF2B2	EIF2B4	ENSDNVP00000002932	ENSDNVP00000002268	Eukaryotic translation initiation factor 2B subunit beta.	Eukaryotic translation initiation factor 2B subunit delta.	0.999

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

0.00172

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

6 of 221

1.47

1.6

6.34e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.04

1.32

0.0041

GO:0022900

Electron transport chain

3 of 61

1.73

0.93

0.0137

GO:0006633

Fatty acid biosynthetic process

3 of 70

1.67

0.89

0.0164

GO:0045454

Cell redox homeostasis

2 of 14

2.2

0.85

0.0272

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004165

delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 4

2.74

1.06

0.0121

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 3

2.86

1.06

0.0121

GO:0000062

fatty-acyl-CoA binding

2 of 8

2.44

0.95

0.0181

GO:0016491

Oxidoreductase activity

7 of 1709

0.65

0.38

0.0449

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 7

2.5

1.06

0.0115

GO:0005739

Mitochondrion

8 of 1098

0.9

0.78

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10559

Beta-ketoacyl synthase, C-terminal domain, and Lipoate metabolic process

2 of 5

2.64

0.82

0.0329

CL:11194

Mixed, incl. Regulation of intracellular lipid transport, and Protein import into peroxisome matrix

2 of 12

2.26

0.78

0.0365

CL:13747

Mixed, incl. Sulfide oxidation to sulfate, and Sulfate assimilation

2 of 27

1.91

0.76

0.0370

CL:11090

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, N-terminal domain

3 of 71

1.67

0.73

0.0365

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

3 of 137

1.38

0.69

0.0328

map00071

Fatty acid degradation

3 of 133

1.39

0.69

0.0328

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.86

1.36

0.0035

MAP-6783984

Glycine degradation

2 of 6

2.56

1.32

0.0039

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 53

1.79

1.21

0.0035

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 16

2.14

0.97

0.0152

MAP-8978868

Fatty acid metabolism

5 of 345

1.2

0.91

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005967

Mitochondrial pyruvate dehydrogenase complex

2 of 5

2.64

1.07

0.0112

GOCC:0005759

Mitochondrial matrix

4 of 165

1.43

0.88

0.0112

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.57

0.0146

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

3 of 9

2.56

2.43

2.99e-05

KW-0520

NAD

2 of 46

1.68

0.71

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 21

2.2

1.54

0.0012

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.22

0.0060

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 10

2.34

0.96

0.0175

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001753

Enoyl-CoA hydratase/isomerase

3 of 22

2.18

1.29

0.0037

IPR029045

ClpP/crotonase-like domain superfamily

3 of 34

1.99

1.15

0.0062

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

2 of 5

2.64

1.08

0.0110

IPR004099

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.08

0.0110

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

2 of 4

2.74

1.08

0.0110

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