GABRB1 protein (Dromaius novaehollandiae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

GABRB1

Gamma-aminobutyric acid type A receptor beta1 subunit. (444 aa)

Predicted Functional Partners:

GABRA1

0.922

GABRA5

0.862

GABRA2

0.859

GABRA3

0.857

GABRD

0.818

GABRG1

0.797

GABRE

0.796

GABRG2

0.794

GABRG3

0.793

GABRA6

0.765

Your Current Organism:

Dromaius novaehollandiae

NCBI taxonomy Id: 8790
Other names: D. novaehollandiae, Dromaius novae-hollandiae, emu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GABRA1	GABRA2	ENSDNVP00000004193	ENSDNVP00000011905	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor alpha2 subunit.	0.928
GABRA1	GABRA3	ENSDNVP00000004193	ENSDNVP00000004962	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor alpha3 subunit.	0.860
GABRA1	GABRA5	ENSDNVP00000004193	ENSDNVP00000025715	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor alpha5 subunit.	0.872
GABRA1	GABRA6	ENSDNVP00000004193	ENSDNVP00000004173	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor alpha6 subunit.	0.752
GABRA1	GABRB1	ENSDNVP00000004193	ENSDNVP00000011932	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor beta1 subunit.	0.922
GABRA1	GABRD	ENSDNVP00000004193	ENSDNVP00000025532	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor delta subunit.	0.871
GABRA1	GABRE	ENSDNVP00000004193	ENSDNVP00000004938	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid receptor subunit gamma-4.	0.901
GABRA1	GABRG1	ENSDNVP00000004193	ENSDNVP00000011892	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor gamma1 subunit.	0.901
GABRA1	GABRG2	ENSDNVP00000004193	ENSDNVP00000004216	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor gamma2 subunit.	0.900
GABRA1	GABRG3	ENSDNVP00000004193	ENSDNVP00000025705	Gamma-aminobutyric acid type A receptor alpha1 subunit.	Gamma-aminobutyric acid type A receptor gamma3 subunit.	0.899
GABRA2	GABRA1	ENSDNVP00000011905	ENSDNVP00000004193	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor alpha1 subunit.	0.928
GABRA2	GABRA3	ENSDNVP00000011905	ENSDNVP00000004962	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor alpha3 subunit.	0.842
GABRA2	GABRA5	ENSDNVP00000011905	ENSDNVP00000025715	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor alpha5 subunit.	0.850
GABRA2	GABRA6	ENSDNVP00000011905	ENSDNVP00000004173	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor alpha6 subunit.	0.733
GABRA2	GABRB1	ENSDNVP00000011905	ENSDNVP00000011932	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor beta1 subunit.	0.859
GABRA2	GABRD	ENSDNVP00000011905	ENSDNVP00000025532	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor delta subunit.	0.918
GABRA2	GABRE	ENSDNVP00000011905	ENSDNVP00000004938	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid receptor subunit gamma-4.	0.836
GABRA2	GABRG1	ENSDNVP00000011905	ENSDNVP00000011892	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor gamma1 subunit.	0.836
GABRA2	GABRG2	ENSDNVP00000011905	ENSDNVP00000004216	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor gamma2 subunit.	0.835
GABRA2	GABRG3	ENSDNVP00000011905	ENSDNVP00000025705	Gamma-aminobutyric acid type A receptor alpha2 subunit.	Gamma-aminobutyric acid type A receptor gamma3 subunit.	0.829

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.886

expected number of edges:

12

PPI enrichment p-value:

2.35e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031929

TOR signaling

4 of 8

2.77

3.41

4.77e-07

GO:0031329

Regulation of cellular catabolic process

5 of 74

1.9

2.4

5.77e-06

GO:0071230

Cellular response to amino acid stimulus

3 of 8

2.64

2.27

6.39e-05

GO:0071038

Nuclear polyadenylation-dependent tRNA catabolic process

3 of 12

2.47

2.16

8.80e-05

GO:0071035

Nuclear polyadenylation-dependent rRNA catabolic process

3 of 12

2.47

2.16

8.80e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0038201

TOR complex

4 of 7

2.82

3.84

7.43e-08

GO:0031932

TORC2 complex

3 of 6

2.77

2.71

1.01e-05

GO:0000176

Nuclear exosome (RNase complex)

3 of 12

2.47

2.33

4.11e-05

GO:1990131

Gtr1-Gtr2 GTPase complex

2 of 2

3.07

1.88

0.00039

GO:0031931

TORC1 complex

2 of 3

2.89

1.78

0.00058

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4006

Mixed, incl. TOR complex, and Gtr1/RagA G protein

7 of 12

2.83

7.61

2.52e-15

CL:4008

Mixed, incl. Gtr1/RagA G protein, and snRNA catabolic process

4 of 6

2.89

4.31

1.06e-08

CL:4020

TORC2 complex

3 of 5

2.85

2.93

4.14e-06

CL:6567

Nuclear polyadenylation-dependent ncRNA catabolic process

2 of 11

2.33

1.15

0.0075

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

3 of 99

1.55

0.92

0.0113

map04136

Autophagy - other

2 of 28

1.92

0.88

0.0211

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-389357

CD28 dependent PI3K/Akt signaling

3 of 6

2.77

2.49

2.66e-05

MAP-6806003

Regulation of TP53 Expression and Degradation

3 of 9

2.59

2.46

2.66e-05

MAP-6804757

Regulation of TP53 Degradation

3 of 9

2.59

2.46

2.66e-05

MAP-5218920

VEGFR2 mediated vascular permeability

3 of 11

2.5

2.44

2.66e-05

MAP-389356

CD28 co-stimulation

3 of 11

2.5

2.44

2.66e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0038201

TOR complex

4 of 8

2.77

3.69

1.36e-07

GOCC:0000178

Exosome (RNase complex)

3 of 13

2.43

2.17

8.24e-05

GOCC:0031931

TORC1 complex

2 of 4

2.77

1.5

0.0019

GOCC:0070209

ASTRA complex

2 of 5

2.67

1.46

0.0022

GOCC:0031932

TORC2 complex

2 of 6

2.59

1.42

0.0025

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006762

Gtr1/RagA G protein

2 of 2

3.07

1.09

0.0109

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