LHX3 protein (Dromaius novaehollandiae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

LHX3

LIM homeobox 3. (357 aa)

Predicted Functional Partners:

ISL1

0.922

ALX3

0.845

LDB1

0.778

LDB2

0.750

SSBP3

0.641

SSBP2

0.641

ENSDNVP00000003510

0.571

DMBX1

0.541

HESX1

0.536

PRRX1

0.533

Your Current Organism:

Dromaius novaehollandiae

NCBI taxonomy Id: 8790
Other names: D. novaehollandiae, Dromaius novae-hollandiae, emu

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX3	LDB1	ENSDNVP00000021701	ENSDNVP00000021227	ALX homeobox 3.	LIM domain binding 1.	0.794
ALX3	LDB2	ENSDNVP00000021701	ENSDNVP00000003476	ALX homeobox 3.	LIM domain binding 2.	0.794
ALX3	LHX3	ENSDNVP00000021701	ENSDNVP00000017109	ALX homeobox 3.	LIM homeobox 3.	0.845
ALX3	SSBP2	ENSDNVP00000021701	ENSDNVP00000019676	ALX homeobox 3.	Single stranded DNA binding protein 2.	0.417
ALX3	SSBP3	ENSDNVP00000021701	ENSDNVP00000015643	ALX homeobox 3.	Single stranded DNA binding protein 3.	0.417
DMBX1	LDB1	ENSDNVP00000012862	ENSDNVP00000021227	Diencephalon/mesencephalon homeobox 1.	LIM domain binding 1.	0.580
DMBX1	LDB2	ENSDNVP00000012862	ENSDNVP00000003476	Diencephalon/mesencephalon homeobox 1.	LIM domain binding 2.	0.580
DMBX1	LHX3	ENSDNVP00000012862	ENSDNVP00000017109	Diencephalon/mesencephalon homeobox 1.	LIM homeobox 3.	0.541
ENSDNVP00000003510	ISL1	ENSDNVP00000003510	ENSDNVP00000005915	annotation not available	ISL LIM homeobox 1.	0.775
ENSDNVP00000003510	LDB1	ENSDNVP00000003510	ENSDNVP00000021227	annotation not available	LIM domain binding 1.	0.658
ENSDNVP00000003510	LDB2	ENSDNVP00000003510	ENSDNVP00000003476	annotation not available	LIM domain binding 2.	0.658
ENSDNVP00000003510	LHX3	ENSDNVP00000003510	ENSDNVP00000017109	annotation not available	LIM homeobox 3.	0.571
HESX1	LDB1	ENSDNVP00000017688	ENSDNVP00000021227	HESX homeobox 1.	LIM domain binding 1.	0.580
HESX1	LDB2	ENSDNVP00000017688	ENSDNVP00000003476	HESX homeobox 1.	LIM domain binding 2.	0.580
HESX1	LHX3	ENSDNVP00000017688	ENSDNVP00000017109	HESX homeobox 1.	LIM homeobox 3.	0.536
ISL1	ENSDNVP00000003510	ENSDNVP00000005915	ENSDNVP00000003510	ISL LIM homeobox 1.	annotation not available	0.775
ISL1	LDB1	ENSDNVP00000005915	ENSDNVP00000021227	ISL LIM homeobox 1.	LIM domain binding 1.	0.876
ISL1	LDB2	ENSDNVP00000005915	ENSDNVP00000003476	ISL LIM homeobox 1.	LIM domain binding 2.	0.853
ISL1	LHX3	ENSDNVP00000005915	ENSDNVP00000017109	ISL LIM homeobox 1.	LIM homeobox 3.	0.922
ISL1	SSBP2	ENSDNVP00000005915	ENSDNVP00000019676	ISL LIM homeobox 1.	Single stranded DNA binding protein 2.	0.491

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.855

expected number of edges:

13

PPI enrichment p-value:

2.76e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000272

Negative regulation of signaling receptor activity

3 of 4

3.06

2.55

2.32e-05

GO:0050730

Regulation of peptidyl-tyrosine phosphorylation

3 of 5

2.96

2.54

2.32e-05

GO:0007166

Cell surface receptor signaling pathway

5 of 147

1.72

1.98

2.64e-05

GO:0006469

Negative regulation of protein kinase activity

3 of 19

2.38

1.97

0.00020

GO:0048585

Negative regulation of response to stimulus

4 of 87

1.85

1.76

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016755

Aminoacyltransferase activity

3 of 7

2.82

2.42

3.67e-05

GO:0017124

SH3 domain binding

3 of 9

2.71

2.41

3.67e-05

GO:0001784

Phosphotyrosine residue binding

3 of 11

2.62

2.39

3.67e-05

GO:0005102

Signaling receptor binding

4 of 59

2.02

2.17

3.67e-05

GO:0019901

Protein kinase binding

3 of 76

1.78

1.25

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 11

2.62

2.29

5.72e-05

GO:0071944

Cell periphery

5 of 929

0.92

0.49

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:662

Mixed, incl. Regulation of cell migration, and Protein tyrosine kinase activity

6 of 61

2.18

4.03

2.71e-09

CL:685

Phosphotyrosine residue binding, and Transmembrane receptor protein kinase activity

3 of 20

2.36

2.07

0.00012

CL:768

VHS domain, and Semaphorin interactions

2 of 5

2.79

1.61

0.0012

CL:688

Mixed, incl. Phosphotyrosine residue binding, and Basal plasma membrane

2 of 13

2.37

1.22

0.0055

CL:1687

Mixed, incl. Protein tyrosine phosphatase, catalytic domain, and EGF-like domain

2 of 28

2.04

0.89

0.0212

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

4 of 223

1.44

1.2

0.0013

map04120

Ubiquitin mediated proteolysis

3 of 173

1.42

0.87

0.0114

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 8

2.76

2.47

2.94e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 14

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024159

Adaptor protein Cbl, PTB domain

3 of 7

2.82

2.21

8.99e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 15

2.49

1.89

0.00030

IPR000980

SH2 domain

3 of 84

1.74

0.81

0.0257

IPR036860

SH2 domain superfamily

3 of 94

1.69

0.79

0.0268

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 93

1.69

0.96

0.0114

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