RND1 protein (Dromaius novaehollandiae) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

RND1

Rho family GTPase 1. (461 aa)

Predicted Functional Partners:

ITSN2

0.998

ITSN1

0.966

PLXNB1

0.948

PLXNB2

0.948

ARHGAP35

0.896

SHANK3

0.865

ANLN

0.857

PLXNA1

0.854

PLXNA4

0.854

PLXNA2

0.854

Your Current Organism:

Dromaius novaehollandiae

NCBI taxonomy Id: 8790
Other names: D. novaehollandiae, Dromaius novae-hollandiae, emu

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANLN	RND1	ENSDNVP00000023881	ENSDNVP00000024012	Anillin actin binding protein.	Rho family GTPase 1.	0.857
ARHGAP35	PLXNA1	ENSDNVP00000002698	ENSDNVP00000004229	Rho GTPase activating protein 35.	Plexin A1.	0.453
ARHGAP35	PLXNA2	ENSDNVP00000002698	ENSDNVP00000017776	Rho GTPase activating protein 35.	Plexin A2.	0.453
ARHGAP35	PLXNA4	ENSDNVP00000002698	ENSDNVP00000015160	Rho GTPase activating protein 35.	plexin-A4.	0.453
ARHGAP35	PLXNB1	ENSDNVP00000002698	ENSDNVP00000003500	Rho GTPase activating protein 35.	Plexin B1.	0.614
ARHGAP35	PLXNB2	ENSDNVP00000002698	ENSDNVP00000022465	Rho GTPase activating protein 35.	Plexin B2.	0.614
ARHGAP35	RND1	ENSDNVP00000002698	ENSDNVP00000024012	Rho GTPase activating protein 35.	Rho family GTPase 1.	0.896
ITSN1	ITSN2	ENSDNVP00000021722	ENSDNVP00000011477	Intersectin 1.	Intersectin 2.	0.981
ITSN1	RND1	ENSDNVP00000021722	ENSDNVP00000024012	Intersectin 1.	Rho family GTPase 1.	0.966
ITSN2	ITSN1	ENSDNVP00000011477	ENSDNVP00000021722	Intersectin 2.	Intersectin 1.	0.981
ITSN2	RND1	ENSDNVP00000011477	ENSDNVP00000024012	Intersectin 2.	Rho family GTPase 1.	0.998
PLXNA1	ARHGAP35	ENSDNVP00000004229	ENSDNVP00000002698	Plexin A1.	Rho GTPase activating protein 35.	0.453
PLXNA1	PLXNB1	ENSDNVP00000004229	ENSDNVP00000003500	Plexin A1.	Plexin B1.	0.526
PLXNA1	PLXNB2	ENSDNVP00000004229	ENSDNVP00000022465	Plexin A1.	Plexin B2.	0.526
PLXNA1	RND1	ENSDNVP00000004229	ENSDNVP00000024012	Plexin A1.	Rho family GTPase 1.	0.854
PLXNA2	ARHGAP35	ENSDNVP00000017776	ENSDNVP00000002698	Plexin A2.	Rho GTPase activating protein 35.	0.453
PLXNA2	PLXNB1	ENSDNVP00000017776	ENSDNVP00000003500	Plexin A2.	Plexin B1.	0.526
PLXNA2	PLXNB2	ENSDNVP00000017776	ENSDNVP00000022465	Plexin A2.	Plexin B2.	0.526
PLXNA2	RND1	ENSDNVP00000017776	ENSDNVP00000024012	Plexin A2.	Rho family GTPase 1.	0.854
PLXNA4	ARHGAP35	ENSDNVP00000015160	ENSDNVP00000002698	plexin-A4.	Rho GTPase activating protein 35.	0.453

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

16

PPI enrichment p-value:

1.33e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

10 of 77

1.98

5.59

4.57e-16

GO:0000470

Maturation of LSU-rRNA

7 of 41

2.09

4.54

4.47e-11

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

6 of 30

2.16

4.16

1.09e-09

GO:0042254

Ribosome biogenesis

11 of 274

1.47

2.94

1.49e-13

GO:0006364

rRNA processing

9 of 204

1.51

2.73

1.85e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043021

Ribonucleoprotein complex binding

3 of 41

1.73

0.75

0.0338

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

9 of 35

2.27

7.01

7.92e-17

GO:0005730

Nucleolus

11 of 215

1.57

3.56

2.69e-15

GO:0005654

Nucleoplasm

4 of 211

1.14

0.77

0.0085

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4695

Preribosome, large subunit precursor, and Ribosomal large subunit export from nucleus

10 of 28

2.42

8.78

2.32e-20

CL:4698

Preribosome, large subunit precursor, and ATPase binding

9 of 21

2.49

8.61

4.01e-19

CL:4684

Preribosome, large subunit precursor, and DEAD/DEAH box helicase domain

11 of 63

2.1

7.28

2.32e-20

CL:4723

Mixed, incl. Circularly permuted (CP)-type guanine nucleotide-binding (G) domain, and ATPase binding

3 of 6

2.56

2.59

1.45e-05

CL:4700

Maturation of LSU-rRNA, and PUA domain

3 of 10

2.34

2.27

4.62e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

6 of 134

1.51

1.86

9.99e-06

MAP-8868773

rRNA processing in the nucleus and cytosol

6 of 138

1.5

1.84

9.99e-06

MAP-72312

rRNA processing

6 of 141

1.49

1.83

9.99e-06

MAP-8953854

Metabolism of RNA

7 of 553

0.96

0.85

0.00046

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030687

Preribosome, large subunit precursor

3 of 22

2.0

1.6

0.00067

GOCC:0031981

Nuclear lumen

8 of 457

1.11

1.2

1.58e-05

GOCC:0005730

Nucleolus

3 of 98

1.35

0.67

0.0345

GOCC:0005634

Nucleus

9 of 1134

0.76

0.66

0.00023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

4 of 18

2.21

2.77

3.05e-06

KW-0698

rRNA processing

3 of 17

2.11

1.85

0.00024

KW-0539

Nucleus

5 of 273

1.13

0.94

0.0014

KW-0489

Methyltransferase

2 of 30

1.69

0.69

0.0458

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 2

2.86

0.89

0.0247

IPR023179

GTP-binding protein, orthogonal bundle domain superfamily

2 of 3

2.69

0.89

0.0247

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