STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE12745.1COGs: COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; InterPro IPR002130; KEGG: pgi:PG1226 peptidyl-prolyl cis-trans isomerase, cyclophilin-type; PFAM: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; SPTR: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; IMG reference gene:2504824704; PFAM: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD. (225 aa)    
Predicted Functional Partners:
AEE13029.1
Heat shock protein Hsp90; COGs: COG0326 Molecular chaperone HSP90 family; InterPro IPR003594:IPR020576; KEGG: pgi:PG0045 heat shock protein 90; PFAM: Heat shock protein Hsp90, C-terminal; ATP-binding region, ATPase-like; SPTR: Hsp90 protein; IMG reference gene:2504825000; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hsp90 protein.
   
 0.906
AEE12379.1
DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR011545:IPR001650:IPR014001; KEGG: pgn:PGN_0150 putative ATP-dependent RNA helicase; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Putative ATP-dependent RNA helicase RhlE; IMG reference gene:2504824306; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.
 
 0.828
AEE12746.1
Protein of unknown function DUF2179; COGs: COG1284 conserved hypothetical protein; InterPro IPR003740:IPR019264; KEGG: pdi:BDI_2028 hypothetical protein; PFAM: Protein of unknown function DUF2179; Protein of unknown function DUF161; SPTR: Putative uncharacterized protein; IMG reference gene:2504824705; PFAM: Uncharacterized BCR, YitT family COG1284; Uncharacterized protein conserved in bacteria (DUF2179).
       0.825
AEE12744.1
Fmu (Sun) domain protein; COGs: COG0144 tRNA and rRNA cytosine-C5-methylase; InterPro IPR001678; KEGG: bvu:BVU_1954 tRNA and rRNA cytosine-C5-methylase; PFAM: Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p; SPTR: NOL1/NOP2/sun family protein; IMG reference gene:2504824703; PFAM: NOL1/NOP2/sun family.
  
    0.822
AEE13356.1
DEAD/DEAH box helicase domain protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR014001:IPR001650:IPR011545:IPR005580; KEGG: pgi:PG0086 DEAD-box ATP dependent DNA helicase; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; DbpA, RNA-binding; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: Putative DEAD-box ATP-dependent RNA helicase CshA; IMG reference gene:2504825344; PFAM: Helicase conserved C-terminal domain; DbpA RNA binding domain; DEAD/DEAH box helicase.
 
 0.801
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 
 
 0.783
AEE12651.1
Manganese/iron superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
   
 
 0.773
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
  
   0.771
rpsQ
30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
   
   0.767
rplO
Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
 
 0.763
Your Current Organism:
Porphyromonas asaccharolytica
NCBI taxonomy Id: 879243
Other names: P. asaccharolytica DSM 20707, Porphyromonas asaccharolytica ATCC 25260, Porphyromonas asaccharolytica CCUG 7834, Porphyromonas asaccharolytica DSM 20707, Porphyromonas asaccharolytica JCM 6326, Porphyromonas asaccharolytica str. DSM 20707, Porphyromonas asaccharolytica strain DSM 20707
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.