STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaKChaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (639 aa)    
Predicted Functional Partners:
grpE
Protein grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
 
 0.998
AEE13029.1
Heat shock protein Hsp90; COGs: COG0326 Molecular chaperone HSP90 family; InterPro IPR003594:IPR020576; KEGG: pgi:PG0045 heat shock protein 90; PFAM: Heat shock protein Hsp90, C-terminal; ATP-binding region, ATPase-like; SPTR: Hsp90 protein; IMG reference gene:2504825000; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hsp90 protein.
   
 0.997
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
 0.997
AEE12641.1
InterPro IPR001623; KEGG: mru:mru_1668 hypothetical protein; PFAM: Heat shock protein DnaJ, N-terminal; SPTR: DnaJ domain protein; IMG reference gene:2504824587; PFAM: DnaJ domain.
  
 0.954
rplP
50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
  
 
 0.947
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.943
clpB
ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.
  
 
 0.927
AEE13030.1
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterPro IPR003593:IPR003959:IPR013093:IPR019489; KEGG: pgn:PGN_0008 ATP-dependent Clp protease ATP-binding subunit ClpC; PFAM: ATPase associated with various cellular activities, AAA-2; ATPase, AAA-type, core; Clp ATPase, C-terminal; SMART: ATPase, AAA+ type, core; SPTR: Putative negative regulator of genetic competence ClpC/MecB; IMG reference gene:2504825001; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; ATPase family associated with various cellular act [...]
  
 
 0.916
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.895
AEE12008.1
InterPro IPR001440:IPR019734; KEGG: pru:PRU_2004 hypothetical protein; PFAM: Tetratricopeptide TPR-1; SPTR: Tetratricopeptide repeat protein; IMG reference gene:2504823927; PFAM: Tetratricopeptide repeat.
  
 0.762
Your Current Organism:
Porphyromonas asaccharolytica
NCBI taxonomy Id: 879243
Other names: P. asaccharolytica DSM 20707, Porphyromonas asaccharolytica ATCC 25260, Porphyromonas asaccharolytica CCUG 7834, Porphyromonas asaccharolytica DSM 20707, Porphyromonas asaccharolytica JCM 6326, Porphyromonas asaccharolytica str. DSM 20707, Porphyromonas asaccharolytica strain DSM 20707
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