STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEE13176.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (857 aa)    
Predicted Functional Partners:
cmk
COGs: COG0283 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR003136:IPR000623:IPR011994; KEGG: pgn:PGN_0646 cytidylate kinase; PFAM: Cytidylate kinase region; Shikimate kinase; PRIAM: Cytidylate kinase; SPTR: Cytidylate kinase; TIGRFAM: Cytidylate kinase; IMG reference gene:2504824995; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
   
 
 0.918
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.916
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
     
 0.911
AEE12873.1
GTP diphosphokinase; COGs: COG0317 Guanosine polyphosphate pyrophosphohydrolase/synthetase; InterPro IPR007685:IPR004095; KEGG: pgn:PGN_0465 GTP pyrophosphokinase; PFAM: RelA/SpoT; TGS; PRIAM: GTP diphosphokinase; SPTR: RelA/SpoT family protein; IMG reference gene:2504824836; PFAM: TGS domain; Region found in RelA / SpoT proteins; TIGRFAM: (p)ppGpp synthetase, RelA/SpoT family.
     
 0.900
AEE13064.1
(p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.900
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
  
 0.799
AEE12490.1
COGs: COG0592 DNA polymerase sliding clamp subunit (PCNA homolog); InterPro IPR001001; KEGG: pgn:PGN_1786 putative DNA polymerase III beta chain; PFAM: DNA polymerase III, beta chain; SMART: DNA polymerase III, beta chain; SPTR: DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta chain; IMG reference gene:2504824420; PFAM: DNA polymerase III beta subunit, N-terminal domain.
   
 
 0.752
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
  
 0.736
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.649
AEE12015.1
KEGG: pgi:PG0698 putative lipoprotein; SPTR: Putative uncharacterized protein; IMG reference gene:2504823934.
 
 
 0.542
Your Current Organism:
Porphyromonas asaccharolytica
NCBI taxonomy Id: 879243
Other names: P. asaccharolytica DSM 20707, Porphyromonas asaccharolytica ATCC 25260, Porphyromonas asaccharolytica CCUG 7834, Porphyromonas asaccharolytica DSM 20707, Porphyromonas asaccharolytica JCM 6326, Porphyromonas asaccharolytica str. DSM 20707, Porphyromonas asaccharolytica strain DSM 20707
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.