A0A0J0XZP8 protein (Cutaneotrichosporon oleaginosum)

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query proteins and first shell of interactors

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

A0A0J0XZP8

Rcd1-domain-containing protein. (404 aa)

Predicted Functional Partners:

A0A0J0XLW1

0.998

A0A0J1AZ40

0.998

A0A0J1B1H4

0.998

A0A0J0XRD8

0.996

A0A0J0XCA2

0.989

A0A0J0XDD2

0.978

A0A0J1B917

0.968

A0A0J0XR01

0.964

A0A0J0XPU5

0.949

A0A0J0XHR6

0.881

Your Current Organism:

Cutaneotrichosporon oleaginosum

NCBI taxonomy Id: 879819
Other names: ATCC 20509, C. oleaginosum, Cutaneotrichosporon oleaginosum (J.J. Zhou, S.O. Suh & Gujjari) Xin Zhan Liu, F.Y. Bai, M. Groenew. & Boekhout, 2015, Trichosporon oleaginosum, Trichosporon oleaginosum J.J. Zhou, S.O. Suh & Gujjari, 2011, Trichosporon oleaginosus, Trichosporon sp. ATCC 20508, Trichosporon sp. ATCC 20509

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0J0XCA2	A0A0J0XDD2	Endo/exonuclease/phosphatase domain-containing protein.	NOT2_3_5 domain-containing protein.	0.958
A0A0J0XCA2	A0A0J0XLW1	Endo/exonuclease/phosphatase domain-containing protein.	Not1-domain-containing protein.	0.996
A0A0J0XCA2	A0A0J0XRD8	Endo/exonuclease/phosphatase domain-containing protein.	RING-type domain-containing protein.	0.988
A0A0J0XCA2	A0A0J0XZP8	Endo/exonuclease/phosphatase domain-containing protein.	Rcd1-domain-containing protein.	0.989
A0A0J0XCA2	A0A0J1AZ40	Endo/exonuclease/phosphatase domain-containing protein.	Putative ccr4-not transcription complex, subunit 7.	0.996
A0A0J0XCA2	A0A0J1B1H4	Endo/exonuclease/phosphatase domain-containing protein.	Uncharacterized protein.	0.984
A0A0J0XCA2	A0A0J1B917	Endo/exonuclease/phosphatase domain-containing protein.	Uncharacterized protein.	0.958
A0A0J0XDD2	A0A0J0XCA2	NOT2_3_5 domain-containing protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.958
A0A0J0XDD2	A0A0J0XLW1	NOT2_3_5 domain-containing protein.	Not1-domain-containing protein.	0.979
A0A0J0XDD2	A0A0J0XPU5	NOT2_3_5 domain-containing protein.	Antiviral helicase.	0.714
A0A0J0XDD2	A0A0J0XR01	NOT2_3_5 domain-containing protein.	Uncharacterized protein.	0.880
A0A0J0XDD2	A0A0J0XRD8	NOT2_3_5 domain-containing protein.	RING-type domain-containing protein.	0.967
A0A0J0XDD2	A0A0J0XZP8	NOT2_3_5 domain-containing protein.	Rcd1-domain-containing protein.	0.978
A0A0J0XDD2	A0A0J1AZ40	NOT2_3_5 domain-containing protein.	Putative ccr4-not transcription complex, subunit 7.	0.978
A0A0J0XDD2	A0A0J1B1H4	NOT2_3_5 domain-containing protein.	Uncharacterized protein.	0.978
A0A0J0XHR6	A0A0J0XPU5	Uncharacterized protein.	Antiviral helicase.	0.877
A0A0J0XHR6	A0A0J0XZP8	Uncharacterized protein.	Rcd1-domain-containing protein.	0.881
A0A0J0XLW1	A0A0J0XCA2	Not1-domain-containing protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.996
A0A0J0XLW1	A0A0J0XDD2	Not1-domain-containing protein.	NOT2_3_5 domain-containing protein.	0.979
A0A0J0XLW1	A0A0J0XR01	Not1-domain-containing protein.	Uncharacterized protein.	0.967

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.921

expected number of edges:

15

PPI enrichment p-value:

9.92e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006085

acetyl-CoA biosynthetic process

4 of 8

2.23

2.36

2.51e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 3

2.35

1.28

0.0042

GO:0022900

Electron transport chain

5 of 96

1.25

1.14

0.00052

GO:0006091

Generation of precursor metabolites and energy

6 of 184

1.04

0.93

0.00054

GO:0032787

Monocarboxylic acid metabolic process

4 of 113

1.08

0.72

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

4 of 8

2.23

2.49

1.32e-05

GO:0016208

AMP binding

2 of 3

2.35

1.15

0.0074

GO:0003987

acetate-CoA ligase activity

2 of 3

2.35

1.15

0.0074

GO:0043169

Cation binding

8 of 564

0.68

0.51

0.0037

GO:0036094

Small molecule binding

8 of 556

0.69

0.51

0.0037

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

3 of 22

1.66

1.09

0.0055

GO:0005829

Cytosol

6 of 316

0.81

0.58

0.0065

GO:0005737

Cytoplasm

9 of 1132

0.43

0.31

0.0214

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1244

Citrate cycle (TCA cycle), and Propanoate metabolism

10 of 30

2.05

6.17

5.15e-17

CL:1245

Citrate cycle (TCA cycle)

6 of 23

1.95

3.42

1.14e-08

CL:1246

Citrate cycle (TCA cycle), and Novobiocin biosynthesis

5 of 14

2.08

3.23

1.40e-07

CL:1292

acetyl-CoA biosynthetic process

4 of 5

2.43

3.2

6.81e-07

CL:1248

Pyruvate ferredoxin/flavodoxin oxidoreductase, and Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.96

1.52e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

daf00620

Pyruvate metabolism

11 of 38

1.99

6.53

6.02e-20

daf00650

Butanoate metabolism

5 of 14

2.08

3.58

1.76e-08

daf01200

Carbon metabolism

11 of 115

1.51

3.3

2.10e-15

daf00010

Glycolysis / Gluconeogenesis

7 of 46

1.71

3.24

6.14e-10

daf00020

Citrate cycle (TCA cycle)

5 of 22

1.89

3.03

8.64e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005618

Cell wall

3 of 12

1.93

1.34

0.0023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

4 of 98

1.14

0.71

0.0154

KW-0479

Metal-binding

6 of 263

0.89

0.61

0.0093

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

4 of 7

2.29

2.62

7.79e-06

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 5

2.13

0.71

0.0481

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 5

2.13

0.71

0.0481

PF13193

AMP-binding enzyme C-terminal domain

2 of 7

1.99

0.7

0.0481

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 16

2.02

2.68

2.24e-06

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.58

9.79e-06

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