Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEL26937.1Aromatic amino acid beta-eliminating lyase/threonine aldolase; PFAM: Beta-eliminating lyase; COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: dfe:Dfer_4745 threonine aldolase; PFAM: Aromatic amino acid beta-eliminating lyase/threonine aldolase; SPTR: Low-specificity L-threonine aldolase. (344 aa)    
Predicted Functional Partners:
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
    
 0.947
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
   
 0.937
AEL24138.1
Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase; COGs: COG0498 Threonine synthase; InterPro IPR001926:IPR004450; KEGG: chu:CHU_0075 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; SPTR: Threonine synthase; TIGRFAM: Threonine synthase.
   
 0.924
AEL26181.1
Pyridoxal-5'-phosphate-dependent protein beta subunit; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: threonine synthase; COGs: COG0498 Threonine synthase; InterPro IPR001926; KEGG: phe:Phep_3574 pyridoxal-5'-phosphate-dependent protein subunit beta; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit; SPTR: Threonine synthase; manually curated.
   
 0.924
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
   
 
 0.909
AEL28063.1
PFAM: Aminotransferase class I and II; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: mtt:Ftrac_1580 glycine C-acetyltransferase; PFAM: Aminotransferase, class I/II; SPTR: 2-amino-3-ketobutyrate CoA ligase.
   
 
 0.909
AEL26936.1
PFAM: Protein of unknown function (DUF2721); KEGG: psn:Pedsa_1226 hypothetical protein; SPTR: Cellulose-binding protein II.
       0.786
ychF
GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
      0.722
AEL26938.1
AAA ATPase central domain protein; PFAM: MgsA AAA+ ATPase C terminal; ATPase family associated with various cellular activities (AAA); COGs: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; InterPro IPR003959:IPR003593; KEGG: cpi:Cpin_0165 ATPase AAA; PFAM: ATPase, AAA-type, core; SMART: ATPase, AAA+ type, core; SPTR: ATPase, AAA family.
       0.664
AEL26934.1
RNA polymerase, sigma-24 subunit, ECF subfamily; PFAM: Sigma-70, region 4; Sigma-70 region 2; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; COGs: COG1595 DNA-directed RNA polymerase specialized sigma subunit sigma24 homolog; InterPro IPR007627:IPR007630:IPR014284; KEGG: mtt:Ftrac_3318 RNA polymerase, sigma-24 subunit, ecf subfamily; PFAM: RNA polymerase sigma-70 region 4; RNA polymerase sigma-70 region 2; SPTR: RNA polymerase, sigma-E factor heat shock and oxidative stress; TIGRFAM: RNA polymerase sigma-70.
       0.432
Your Current Organism:
Cyclobacterium marinum
NCBI taxonomy Id: 880070
Other names: C. marinum DSM 745, Cyclobacterium marinum DSM 745, Cyclobacterium marinum LMG 13164, Cyclobacterium marinum str. DSM 745, Cyclobacterium marinum strain DSM 745
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