AFM04021.1 protein (Bernardetia litoralis) - STRING interaction network

Nodes:

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

AFM04021.1

Outer membrane protein/protective antigen OMA87; PFAM: Surface antigen variable number repeat; Surface antigen. (622 aa)

Predicted Functional Partners:

AFM03891.1

0.775

AFM06276.1

0.775

AFM03890.1

0.771

AFM06209.1

0.760

AFM02903.1

0.736

AFM02963.1

0.728

AFM02806.1

0.725

AFM06253.1

0.714

AFM03911.1

0.700

AFM03032.1

0.695

Your Current Organism:

Bernardetia litoralis

NCBI taxonomy Id: 880071
Other names: B. litoralis DSM 6794, Bernardetia litoralis DSM 6794, Flexibacter litoralis ATCC 23117, Flexibacter litoralis DSM 6794, Flexibacter litoralis IFO 15988

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFM02806.1	AFM02963.1	Fleli_0319	Fleli_0487	Hypothetical protein.	PFAM: TonB-dependent Receptor Plug Domain.	0.775
AFM02806.1	AFM03890.1	Fleli_0319	Fleli_1464	Hypothetical protein.	Hypothetical protein.	0.598
AFM02806.1	AFM03891.1	Fleli_0319	Fleli_1465	Hypothetical protein.	Hypothetical protein.	0.749
AFM02806.1	AFM04021.1	Fleli_0319	Fleli_1603	Hypothetical protein.	Outer membrane protein/protective antigen OMA87; PFAM: Surface antigen variable number repeat; Surface antigen.	0.725
AFM02806.1	AFM06276.1	Fleli_0319	Fleli_3974	Hypothetical protein.	Hypothetical protein.	0.712
AFM02903.1	AFM03032.1	Fleli_0427	Fleli_0565	PFAM: Glycosyl transferases group 1.	Hypothetical protein.	0.704
AFM02903.1	AFM03890.1	Fleli_0427	Fleli_1464	PFAM: Glycosyl transferases group 1.	Hypothetical protein.	0.761
AFM02903.1	AFM03891.1	Fleli_0427	Fleli_1465	PFAM: Glycosyl transferases group 1.	Hypothetical protein.	0.539
AFM02903.1	AFM04021.1	Fleli_0427	Fleli_1603	PFAM: Glycosyl transferases group 1.	Outer membrane protein/protective antigen OMA87; PFAM: Surface antigen variable number repeat; Surface antigen.	0.736
AFM02903.1	AFM06209.1	Fleli_0427	Fleli_3906	PFAM: Glycosyl transferases group 1.	Hypothetical protein.	0.770
AFM02903.1	AFM06276.1	Fleli_0427	Fleli_3974	PFAM: Glycosyl transferases group 1.	Hypothetical protein.	0.557
AFM02963.1	AFM02806.1	Fleli_0487	Fleli_0319	PFAM: TonB-dependent Receptor Plug Domain.	Hypothetical protein.	0.775
AFM02963.1	AFM03890.1	Fleli_0487	Fleli_1464	PFAM: TonB-dependent Receptor Plug Domain.	Hypothetical protein.	0.420
AFM02963.1	AFM03891.1	Fleli_0487	Fleli_1465	PFAM: TonB-dependent Receptor Plug Domain.	Hypothetical protein.	0.748
AFM02963.1	AFM04021.1	Fleli_0487	Fleli_1603	PFAM: TonB-dependent Receptor Plug Domain.	Outer membrane protein/protective antigen OMA87; PFAM: Surface antigen variable number repeat; Surface antigen.	0.728
AFM02963.1	AFM06276.1	Fleli_0487	Fleli_3974	PFAM: TonB-dependent Receptor Plug Domain.	Hypothetical protein.	0.714
AFM03032.1	AFM02903.1	Fleli_0565	Fleli_0427	Hypothetical protein.	PFAM: Glycosyl transferases group 1.	0.704
AFM03032.1	AFM03890.1	Fleli_0565	Fleli_1464	Hypothetical protein.	Hypothetical protein.	0.709
AFM03032.1	AFM03891.1	Fleli_0565	Fleli_1465	Hypothetical protein.	Hypothetical protein.	0.577
AFM03032.1	AFM04021.1	Fleli_0565	Fleli_1603	Hypothetical protein.	Outer membrane protein/protective antigen OMA87; PFAM: Surface antigen variable number repeat; Surface antigen.	0.695

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.867

expected number of edges:

19

PPI enrichment p-value:

0.0241

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016558

Protein import into peroxisome matrix

5 of 23

2.55

4.1

1.33e-08

GO:0016560

Protein import into peroxisome matrix, docking

3 of 9

2.73

2.62

1.49e-05

GO:0046474

Glycerophospholipid biosynthetic process

5 of 169

1.68

2.03

1.49e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043337

CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity

3 of 3

3.21

2.82

8.01e-06

GO:0008808

Cardiolipin synthase activity

3 of 3

3.21

2.82

8.01e-06

GO:0005052

Peroxisome matrix targeting signal-1 binding

2 of 2

3.21

1.67

0.00096

GO:0008022

Protein C-terminus binding

2 of 4

2.91

1.49

0.0020

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005778

Peroxisomal membrane

5 of 57

2.15

3.24

1.95e-07

GO:0005779

Integral component of peroxisomal membrane

2 of 17

2.28

1.08

0.0099

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21968

Biosynthesis of maresins, and Synthesis of CL

6 of 17

2.76

6.02

3.18e-12

CL:21973

Synthesis of CL, and Biosynthesis of maresins

5 of 11

2.87

5.34

1.03e-10

CL:17276

Protein import into peroxisome matrix, and SCP2 sterol-binding domain

5 of 14

2.76

5.13

2.03e-10

CL:21974

Synthesis of CL, and Biosynthesis of maresins

3 of 6

2.91

3.08

2.26e-06

CL:21985

Mixed, incl. Synthesis of CL, and Gti1/Pac2 family

2 of 5

2.81

1.69

0.00083

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04146

Peroxisome

6 of 209

1.67

2.55

1.90e-07

map00564

Glycerophospholipid metabolism

5 of 200

1.61

2.04

6.33e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482925

Acyl chain remodelling of PG

5 of 21

2.59

4.53

1.97e-09

MAP-1483076

Synthesis of CL

3 of 3

3.21

3.18

1.72e-06

MAP-1483206

Glycerophospholipid biosynthesis

5 of 150

1.73

2.24

5.04e-06

MAP-1483257

Phospholipid metabolism

5 of 203

1.6

1.91

1.76e-05

MAP-9033241

Peroxisomal protein import

6 of 317

1.49

1.9

4.69e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005778

Peroxisomal membrane

5 of 124

1.82

2.23

1.04e-05

GOCC:1990429

Peroxisomal importomer complex

2 of 2

3.21

1.82

0.00053

GOCC:0005779

Integral component of peroxisomal membrane

2 of 8

2.61

1.36

0.0033

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 5493

0.47

0.35

0.0086

GOCC:0005737

Cytoplasm

10 of 5560

0.47

0.35

0.0086

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13344

Haloacid dehalogenase-like hydrolase

3 of 6

2.91

2.41

3.98e-05

PF13242

HAD-hyrolase-like

3 of 12

2.61

2.14

0.00011

PF04757

Pex2 / Pex12 amino terminal region

2 of 6

2.73

1.13

0.0088

PF01066

CDP-alcohol phosphatidyltransferase

2 of 10

2.51

0.99

0.0155

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006353

HAD-superfamily hydrolase, subfamily IIA, CECR5

3 of 4

3.09

2.4

4.42e-05

IPR006357

HAD-superfamily hydrolase, subfamily IIA

3 of 6

2.91

2.35

5.31e-05

IPR024111

PEX5/PEX5L

2 of 2

3.21

1.28

0.0050

IPR017375

Peroxisome assembly protein 12

2 of 2

3.21

1.28

0.0050

IPR006845

Pex, N-terminal

2 of 6

2.73

1.02

0.0141

(more ...)

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