STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisCCOGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR005861:IPR004839; KEGG: sfu:Sfum_2116 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/classII; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase 2; TIGRFAM: Histidinol-phosphate aminotransferase; IMG reference gene:2504153540; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransfera [...] (366 aa)    
Predicted Functional Partners:
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR000807; KEGG: sfu:Sfum_4004 imidazoleglycerol-phosphate dehydratase; PFAM: Imidazoleglycerol-phosphate dehydratase; PRIAM: Imidazoleglycerol-phosphate dehydratase; SPTR: Imidazoleglycerol-phosphate dehydratase; IMG reference gene:2504156375; PFAM: Imidazoleglycerol-phosphate dehydratase.
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.994
AEB10502.1
Chorismate mutase; COGs: COG0287 Prephenate dehydrogenase; InterPro IPR003099; KEGG: sat:SYN_01933 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase; PRIAM: Chorismate mutase; SPTR: Prephenate dehydrogenase; IMG reference gene:2504156249; PFAM: Prephenate dehydrogenase.
  
 
 0.979
AEB08532.1
COGs: COG0077 Prephenate dehydratase; InterPro IPR002701:IPR020822:IPR001086:IPR002912; KEGG: glo:Glov_2150 chorismate mutase; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT; SMART: Chorismate mutase; SPTR: Chorismate mutase; IMG reference gene:2504154179; PFAM: Prephenate dehydratase; ACT domain; Chorismate mutase type II.
  
 
 0.955
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
  
  
 0.946
hisA
1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; InterPro IPR006062:IPR006063:IPR023016; KEGG: sfu:Sfum_1215 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR:1-(5-phosphoribosyl)-5-[(5- phosphor [...]
  
  
 0.925
AEB10248.1
COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: glo:Glov_1768 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Aspartate transaminase; SPTR: Aminotransferase class I and II; IMG reference gene:2504155986; PFAM: Aminotransferase class I and II.
 
 
0.918
cmk
COGs: COG0283 Cytidylate kinase; HAMAP: Cytidylate kinase; InterPro IPR003136:IPR011994; KEGG: cya:CYA_2663 bifunctional pantoate ligase/cytidylate kinase; PFAM: Cytidylate kinase domain; SPTR: Bifunctional pantoate ligase/cytidylate kinase; TIGRFAM: Cytidylate kinase; IMG reference gene:2504153541; PFAM: Cytidylate kinase; TIGRFAM: cytidylate kinase.
 
    0.908
AEB08271.1
COGs: COG0436 Aspartate/tyrosine/aromatic aminotransferase; InterPro IPR004839; KEGG: dak:DaAHT2_0099 aminotransferase class I and II; PFAM: Aminotransferase, class I/classII; PRIAM: Aspartate transaminase; SPTR: Aminotransferase class I and II; IMG reference gene:2504153901; PFAM: Aminotransferase class I and II.
  
 
0.908
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
  
 0.895
Your Current Organism:
Desulfobacca acetoxidans
NCBI taxonomy Id: 880072
Other names: D. acetoxidans DSM 11109, Desulfobacca acetoxidans DSM 11109, Desulfobacca acetoxidans str. DSM 11109, Desulfobacca acetoxidans strain DSM 11109
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