STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB08078.1Phosphomethylpyrimidine kinase; COGs: COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; InterPro IPR004399:IPR013749:IPR019293; KEGG: kcr:Kcr_0867 phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1; Phosphomethylpyrimidine kinase; PRIAM: Phosphomethylpyrimidine kinase; SPTR: Phosphomethylpyrimidine kinase; TIGRFAM: Phosphomethylpyrimidine kinase type-2; IMG reference gene:2504153702; PFAM: Phosphomethylpyrimidine kinase; Archaeal phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase. (446 aa)    
Predicted Functional Partners:
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
 0.999
thiM
Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.
 
 0.999
thiC
Phosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
 
 0.997
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
    
 0.932
AEB08013.1
COGs: COG1785 Alkaline phosphatase; InterPro IPR001952:IPR011449; KEGG: dly:Dehly_1316 alkaline phosphatase; PFAM: Alkaline phosphatase; PEP-CTERM bacterial; SMART: Alkaline phosphatase; SPTR: Alkaline phosphatase; IMG reference gene:2504153635; PFAM: Alkaline phosphatase; Belongs to the alkaline phosphatase family.
    
 0.907
AEB08552.1
COGs: COG1785 Alkaline phosphatase; InterPro IPR001952; KEGG: dbr:Deba_2477 alkaline phosphatase; PFAM: Alkaline phosphatase; PRIAM: Alkaline phosphatase; SMART: Alkaline phosphatase; SPTR: Alkaline phosphatase; IMG reference gene:2504154199; PFAM: Alkaline phosphatase; Belongs to the alkaline phosphatase family.
    
 0.907
thi4
Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.
 
  
 0.801
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.697
AEB10135.1
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: tpe:Tpen_1822 UBA/ThiF-type NAD/FAD binding protein; PFAM: UBA/THIF-type NAD/FAD binding fold; MoeZ/MoeB; SPTR: UBA/THIF-type NAD/FAD binding protein; IMG reference gene:2504155869; PFAM: MoeZ/MoeB domain; ThiF family.
 
  
 0.659
AEB09694.1
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594; KEGG: ccs:CCNA_03842 molybdopterin biosynthesis MoeB protein; PFAM: UBA/THIF-type NAD/FAD binding fold; SPTR: UBA/THIF-type NAD/FAD binding protein; IMG reference gene:2504155405; PFAM: ThiF family.
  
  
 0.598
Your Current Organism:
Desulfobacca acetoxidans
NCBI taxonomy Id: 880072
Other names: D. acetoxidans DSM 11109, Desulfobacca acetoxidans DSM 11109, Desulfobacca acetoxidans str. DSM 11109, Desulfobacca acetoxidans strain DSM 11109
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