STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB08869.1COGs: COG0680 Ni Fe-hydrogenase maturation factor; InterPro IPR000671; KEGG: dat:HRM2_11700 HyaD2; PFAM: Peptidase A31, hydrogen uptake protein; SPTR: HyaD2; TIGRFAM: Peptidase A31, hydrogen uptake protein; IMG reference gene:2504154535; PFAM: Hydrogenase maturation protease; TIGRFAM: hydrogenase maturation protease. (183 aa)    
Predicted Functional Partners:
gpmA
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
    
   0.731
hypA
Hydrogenase expression/synthesis HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
  
  
 0.602
AEB10697.1
Hydrogenase expression/formation protein HypD; COGs: COG0409 Hydrogenase maturation factor; InterPro IPR002780; KEGG: sfu:Sfum_4014 hydrogenase expression/formation protein HypD; PFAM: Hydrogenase formation HypD protein; SPTR: Hydrogenase expression/formation protein HypD; TIGRFAM: Hydrogenase formation HypD protein; IMG reference gene:2504156469; PFAM: Hydrogenase formation hypA family; TIGRFAM: hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
   
 0.594
AEB10695.1
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.584
AEB10244.1
Hydrogenase expression/formation protein HypE; COGs: COG0309 Hydrogenase maturation factor; InterPro IPR000728:IPR010918:IPR011854; KEGG: rme:Rmet_1540 hydrogenase expression/formation protein HypE; PFAM: AIR synthase-related protein, C-terminal; AIR synthase-related protein; SPTR: Putative uncharacterized protein; TIGRFAM: Hydrogenase expression/formation protein HypE; IMG reference gene:2504155982; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
 
   
 0.546
AEB08868.1
Methyltransferase-16; InterPro IPR019410; KEGG: sfu:Sfum_0452 methyltransferase type 12; PFAM: Methyltransferase-16, putative; SPTR: Methyltransferase type 12; IMG reference gene:2504154534; PFAM: Putative methyltransferase.
 
 
   0.518
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
    
   0.509
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
   
   0.475
AEB08871.1
Hypothetical protein; COGs: COG4802 Ferredoxin-thioredoxin reductase catalytic subunit; KEGG: dol:Dole_2967 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504154537; PFAM: Ferredoxin thioredoxin reductase catalytic beta chain.
  
     0.471
AEB08941.1
SufBD protein; COGs: COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component; InterPro IPR000825; KEGG: sfu:Sfum_0163 SufBD protein; PFAM: SUF system FeS cluster assembly, SufBD; SPTR: SufBD protein; IMG reference gene:2504154610; PFAM: Uncharacterized protein family (UPF0051).
  
     0.409
Your Current Organism:
Desulfobacca acetoxidans
NCBI taxonomy Id: 880072
Other names: D. acetoxidans DSM 11109, Desulfobacca acetoxidans DSM 11109, Desulfobacca acetoxidans str. DSM 11109, Desulfobacca acetoxidans strain DSM 11109
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