STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas1-3CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (349 aa)    
Predicted Functional Partners:
cas2-3
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.979
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.956
AEB09150.1
RNA-directed DNA polymerase (Reverse transcriptase); COGs: COG3344 Retron-type reverse transcriptase; InterPro IPR000477; KEGG: pph:Ppha_2459 CRISPR-associated protein Cas1; PFAM: Reverse transcriptase; SPTR: Putative uncharacterized protein; IMG reference gene:2504154831; PFAM: Reverse transcriptase (RNA-dependent DNA polymerase).
      0.905
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.848
AEB08978.1
KEGG: mpt:Mpe_A3768 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504154650.
  
 
 0.808
AEB07984.1
CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
 
 
 0.800
AEB07990.1
CRISPR-associated helicase Cas3; COGs: COG1203 helicase; InterPro IPR006474:IPR014001:IPR001650:IPR011545; KEGG: tye:THEYE_A1088 CRISPR-associated helicase Cas3; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; Helicase, C-terminal; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: Helicase Cas3, CRISPR-associated, core; IMG reference gene:2504153611; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3.
 
  
 0.762
AEB09561.1
CRISPR-associated protein, Csm1 family; COGs: COG1353 hydrolase of the HD superfamily (permuted catalytic motifs); InterPro IPR000160:IPR013408; KEGG: saf:SULAZ_1602 crispr-associated protein, Csm1 family; PFAM: Diguanylate cyclase, predicted; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein Csm1; IMG reference gene:2504155269; TIGRFAM: CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE.
 
  
 0.676
AEB09563.1
CRISPR-associated RAMP protein, Csm3 family; COGs: COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR005537:IPR013412; KEGG: saf:SULAZ_1604 crispr-associated RAMP protein, Csm3 family; PFAM: Protein of unknown function DUF324; SPTR: Uncharacterized protein MTH_1080; TIGRFAM: CRISPR-associated RAMP Csm3; IMG reference gene:2504155271; PFAM: RAMP superfamily; TIGRFAM: CRISPR type III-A/MTUBE-associated RAMP protein Csm3.
 
     0.651
AEB09573.1
Tetratricopeptide TPR_2 repeat-containing protein; COGs: COG4951 conserved hypothetical protein; InterPro IPR013105; KEGG: sfu:Sfum_1354 hypothetical protein; PFAM: Tetratricopeptide TPR2; SPTR: Putative uncharacterized protein; IMG reference gene:2504155281.
 
     0.522
Your Current Organism:
Desulfobacca acetoxidans
NCBI taxonomy Id: 880072
Other names: D. acetoxidans DSM 11109, Desulfobacca acetoxidans DSM 11109, Desulfobacca acetoxidans str. DSM 11109, Desulfobacca acetoxidans strain DSM 11109
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