STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
AEB10387.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (461 aa)    
Predicted Functional Partners:
dnaG
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 0.956
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
   
 
 0.875
AEB08419.1
P4 alpha zinc-binding domain protein; COGs: COG0358 DNA primase; InterPro IPR013237:IPR002694; KEGG: dal:Dalk_0267 P4 alpha zinc-binding domain protein; PFAM: Phage P4 alpha, zinc-binding; SMART: Phage P4 alpha, zinc-binding; Zinc finger, CHC2-type; SPTR: P4 alpha zinc-binding domain protein; IMG reference gene:2504154058; PFAM: Zinc-binding domain of primase-helicase.
  
 
 0.853
AEB07945.1
IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR003593:IPR002611; KEGG: mta:Moth_2240 IstB-like ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: IstB-like ATP-binding protein; IMG reference gene:2504153565; PFAM: IstB-like ATP binding protein.
  
 
 0.852
AEB07982.1
IstB domain protein ATP-binding protein; COGs: COG1484 DNA replication protein; InterPro IPR003593:IPR002611; KEGG: mta:Moth_2240 IstB-like ATP-binding protein; PFAM: IstB-like ATP-binding protein; SMART: ATPase, AAA+ type, core; SPTR: IstB-like ATP-binding protein; IMG reference gene:2504153603; PFAM: IstB-like ATP binding protein.
  
 
 0.852
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.798
AEB09705.1
UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: nde:NIDE1291 ATP-dependent DNA helicase; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase; IMG reference gene:2504155416; PFAM: UvrD/REP helicase.
 
 
 0.739
AEB09972.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; InterPro IPR004622; KEGG: pth:PTH_0063 DNA polymerase III, gamma/tau subunits; SPTR: DNA polymerase III, delta' subunit; TIGRFAM: DNA polymerase III, delta prime subunit; IMG reference gene:2504155697; TIGRFAM: DNA polymerase III, delta' subunit; DNA polymerase III, subunit gamma and tau.
 
 
 
 0.736
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 
 0.701
AEB09739.1
COGs: COG0629 Single-stranded DNA-binding protein; InterPro IPR011344:IPR000424; KEGG: ppd:Ppro_0449 single-strand binding protein; PFAM: Primosome PriB/single-strand DNA-binding; SPTR: Single-stranded DNA-binding protein; TIGRFAM: Single-strand DNA-binding; IMG reference gene:2504155451; PFAM: Single-strand binding protein family; TIGRFAM: single stranded DNA-binding protein (ssb).
 
 
 0.681
Your Current Organism:
Desulfobacca acetoxidans
NCBI taxonomy Id: 880072
Other names: D. acetoxidans DSM 11109, Desulfobacca acetoxidans DSM 11109, Desulfobacca acetoxidans str. DSM 11109, Desulfobacca acetoxidans strain DSM 11109
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