APF17818.1 protein (Caldithrix abyssi) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

APF17818.1

PAS domain S-box-containing protein. (409 aa)

Predicted Functional Partners:

Cabys_977

0.874

Cabys_499

0.833

APF17819.1

0.720

APF20290.1

0.639

APF20080.1

0.633

APF19751.1

0.626

APF18761.1

0.623

Cabys_790

0.617

APF19231.1

0.616

APF19982.1

0.613

Your Current Organism:

Caldithrix abyssi

NCBI taxonomy Id: 880073
Other names: C. abyssi DSM 13497, Caldithrix abyssi DSM 13497, Caldithrix abyssi LF13, Caldithrix abyssi str. DSM 13497, Caldithrix abyssi strain DSM 13497

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APF17818.1	APF17819.1	Cabys_1069	Cabys_1070	PAS domain S-box-containing protein.	Response regulator receiver domain-containing protein.	0.720
APF17818.1	APF18761.1	Cabys_1069	Cabys_2012	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.623
APF17818.1	APF19231.1	Cabys_1069	Cabys_2482	PAS domain S-box-containing protein.	Signal transduction histidine kinase.	0.616
APF17818.1	APF19751.1	Cabys_1069	Cabys_3003	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.626
APF17818.1	APF19982.1	Cabys_1069	Cabys_3234	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.613
APF17818.1	APF20080.1	Cabys_1069	Cabys_3332	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.633
APF17818.1	APF20290.1	Cabys_1069	Cabys_3544	PAS domain S-box-containing protein.	His Kinase A (phospho-acceptor) domain-containing protein.	0.639
APF17818.1	Cabys_499	Cabys_1069	Cabys_499	PAS domain S-box-containing protein.	PAS domain S-box-containing protein.	0.833
APF17818.1	Cabys_790	Cabys_1069	Cabys_790	PAS domain S-box-containing protein.	Hypothetical protein.	0.617
APF17818.1	Cabys_977	Cabys_1069	Cabys_977	PAS domain S-box-containing protein.	Response regulator receiver domain-containing protein.	0.874
APF17819.1	APF17818.1	Cabys_1070	Cabys_1069	Response regulator receiver domain-containing protein.	PAS domain S-box-containing protein.	0.720
APF17819.1	APF18761.1	Cabys_1070	Cabys_2012	Response regulator receiver domain-containing protein.	PAS domain S-box-containing protein.	0.936
APF17819.1	APF19231.1	Cabys_1070	Cabys_2482	Response regulator receiver domain-containing protein.	Signal transduction histidine kinase.	0.909
APF17819.1	APF19751.1	Cabys_1070	Cabys_3003	Response regulator receiver domain-containing protein.	PAS domain S-box-containing protein.	0.942
APF17819.1	APF19982.1	Cabys_1070	Cabys_3234	Response regulator receiver domain-containing protein.	PAS domain S-box-containing protein.	0.914
APF17819.1	APF20080.1	Cabys_1070	Cabys_3332	Response regulator receiver domain-containing protein.	PAS domain S-box-containing protein.	0.922
APF17819.1	APF20290.1	Cabys_1070	Cabys_3544	Response regulator receiver domain-containing protein.	His Kinase A (phospho-acceptor) domain-containing protein.	0.916
APF17819.1	Cabys_499	Cabys_1070	Cabys_499	Response regulator receiver domain-containing protein.	PAS domain S-box-containing protein.	0.945
APF17819.1	Cabys_790	Cabys_1070	Cabys_790	Response regulator receiver domain-containing protein.	Hypothetical protein.	0.883
APF17819.1	Cabys_977	Cabys_1070	Cabys_977	Response regulator receiver domain-containing protein.	Response regulator receiver domain-containing protein.	0.951

page 1 of 6

Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000724

Double-strand break repair via homologous recombination

3 of 4

2.43

1.93

0.00054

GO:0006281

DNA repair

4 of 50

1.46

1.23

0.0020

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003690

Double-stranded DNA binding

3 of 14

1.89

1.25

0.0057

GO:0003678

DNA helicase activity

3 of 14

1.89

1.25

0.0057

GO:0004527

Exonuclease activity

3 of 20

1.73

1.2

0.0057

GO:0016887

ATP hydrolysis activity

3 of 41

1.42

0.86

0.0179

GO:0008408

3-5 exonuclease activity

2 of 9

1.9

0.86

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033202

DNA helicase complex

3 of 8

2.13

2.0

0.00027

GO:1902494

Catalytic complex

4 of 68

1.33

1.21

0.00092

GO:0032991

Protein-containing complex

5 of 170

1.03

0.88

0.0011

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1230

PD-(D/E)XK nuclease superfamily, and CBS domain

4 of 6

2.38

3.11

3.40e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033202

DNA helicase complex

3 of 13

1.92

1.48

0.0020

GOCC:0044815

DNA packaging complex

3 of 15

1.86

1.46

0.0020

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0269

Exonuclease

3 of 11

1.99

1.9

0.00033

KW-0234

DNA repair

4 of 31

1.67

1.72

0.00024

KW-0227

DNA damage

4 of 31

1.67

1.72

0.00024

KW-0347

Helicase

3 of 20

1.73

1.5

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13361

UvrD-like helicase C-terminal domain

3 of 3

2.56

2.31

0.00013

PF12705

PD-(D/E)XK nuclease superfamily

3 of 4

2.43

2.28

0.00013

PF13245

AAA domain

2 of 5

2.16

0.99

0.0212

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038726

PD-(D/E)XK endonuclease-like domain, AddAB-type

3 of 4

2.43

1.92

0.00058

IPR011604

PD-(D/E)XK endonuclease-like domain superfamily

3 of 4

2.43

1.92

0.00058

IPR011335

Restriction endonuclease type II-like

3 of 7

2.19

1.82

0.00067

IPR014016

UvrD-like helicase, ATP-binding domain

3 of 8

2.13

1.8

0.00068

IPR000212

DNA helicase, UvrD/REP type

3 of 8

2.13

1.8

0.00068

(more ...)

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