APF18757.1 protein (Caldithrix abyssi) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

APF18757.1

Molybdate transporter of MFS superfamily protein. (407 aa)

Predicted Functional Partners:

moaA

0.916

acyl

0.850

APF19663.1

0.844

APF19051.1

0.834

nuoM

0.821

nuoM-2

0.821

APF18008.1

0.798

APF19306.1

0.798

APF18759.1

0.794

APF18758.1

0.782

Your Current Organism:

Caldithrix abyssi

NCBI taxonomy Id: 880073
Other names: C. abyssi DSM 13497, Caldithrix abyssi DSM 13497, Caldithrix abyssi LF13, Caldithrix abyssi str. DSM 13497, Caldithrix abyssi strain DSM 13497

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APF18008.1	APF18757.1	Cabys_1259	Cabys_2008	Cytochrome b/b6/petB.	Molybdate transporter of MFS superfamily protein.	0.798
APF18008.1	APF19663.1	Cabys_1259	Cabys_2915	Cytochrome b/b6/petB.	Ankyrin repeat-containing protein.	0.806
APF18008.1	acyl	Cabys_1259	Cabys_1399	Cytochrome b/b6/petB.	Acyl transferase domain-containing protein.	0.834
APF18008.1	nuoM	Cabys_1259	Cabys_1522	Cytochrome b/b6/petB.	NADH dehydrogenase subunit M.	0.958
APF18008.1	nuoM-2	Cabys_1259	Cabys_4045	Cytochrome b/b6/petB.	NADH dehydrogenase subunit M.	0.954
APF18757.1	APF18008.1	Cabys_2008	Cabys_1259	Molybdate transporter of MFS superfamily protein.	Cytochrome b/b6/petB.	0.798
APF18757.1	APF18758.1	Cabys_2008	Cabys_2009	Molybdate transporter of MFS superfamily protein.	Molybdenum cofactor biosynthesis protein MoaC.	0.782
APF18757.1	APF18759.1	Cabys_2008	Cabys_2010	Molybdate transporter of MFS superfamily protein.	Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.794
APF18757.1	APF19051.1	Cabys_2008	Cabys_2302	Molybdate transporter of MFS superfamily protein.	Octaheme c-type cytochrome, tetrathionate reductase family.	0.834
APF18757.1	APF19306.1	Cabys_2008	Cabys_2557	Molybdate transporter of MFS superfamily protein.	Ubiquinol-cytochrome c reductase cytochrome b subunit/cytochrome b6.	0.798
APF18757.1	APF19663.1	Cabys_2008	Cabys_2915	Molybdate transporter of MFS superfamily protein.	Ankyrin repeat-containing protein.	0.844
APF18757.1	acyl	Cabys_2008	Cabys_1399	Molybdate transporter of MFS superfamily protein.	Acyl transferase domain-containing protein.	0.850
APF18757.1	moaA	Cabys_2008	Cabys_2007	Molybdate transporter of MFS superfamily protein.	moaA cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.	0.916
APF18757.1	nuoM	Cabys_2008	Cabys_1522	Molybdate transporter of MFS superfamily protein.	NADH dehydrogenase subunit M.	0.821
APF18757.1	nuoM-2	Cabys_2008	Cabys_4045	Molybdate transporter of MFS superfamily protein.	NADH dehydrogenase subunit M.	0.821
APF18758.1	APF18757.1	Cabys_2009	Cabys_2008	Molybdenum cofactor biosynthesis protein MoaC.	Molybdate transporter of MFS superfamily protein.	0.782
APF18758.1	APF18759.1	Cabys_2009	Cabys_2010	Molybdenum cofactor biosynthesis protein MoaC.	Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	0.999
APF18758.1	moaA	Cabys_2009	Cabys_2007	Molybdenum cofactor biosynthesis protein MoaC.	moaA cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.	0.999
APF18759.1	APF18757.1	Cabys_2010	Cabys_2008	Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	Molybdate transporter of MFS superfamily protein.	0.794
APF18759.1	APF18758.1	Cabys_2010	Cabys_2009	Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.	Molybdenum cofactor biosynthesis protein MoaC.	0.999

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.82

expected number of edges:

11

PPI enrichment p-value:

0.00876

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006569

Tryptophan catabolic process

5 of 14

2.82

4.88

7.47e-10

GO:0034354

De novo NAD biosynthetic process from tryptophan

5 of 16

2.77

4.85

7.47e-10

GO:0042537

Benzene-containing compound metabolic process

5 of 46

2.31

4.0

7.88e-09

GO:0043420

Anthranilate metabolic process

3 of 5

3.05

3.3

9.72e-07

GO:0019805

Quinolinate biosynthetic process

3 of 5

3.05

3.3

9.72e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004502

Kynurenine 3-monooxygenase activity

3 of 3

3.27

2.93

5.05e-06

GO:0004474

Malate synthase activity

2 of 4

2.97

1.4

0.0029

GO:0046564

Oxalate decarboxylase activity

2 of 5

2.87

1.39

0.0030

GO:0071949

FAD binding

3 of 147

1.58

0.79

0.0250

GO:0003824

Catalytic activity

11 of 8442

0.39

0.28

0.0250

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009514

Glyoxysome

2 of 6

2.79

1.18

0.0072

GO:0005782

Peroxisomal matrix

2 of 19

2.29

0.97

0.0161

GO:0005741

Mitochondrial outer membrane

3 of 119

1.67

0.89

0.0161

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27157477

(2016) Transcriptomic profile of tobacco in response to Alternaria longipes and Alternaria alternata infections.

2 of 2

3.27

1.97

0.00028

PMID:35205907

(2022) Lauric Acid Induces Apoptosis of Rice Sheath Blight Disease Caused by Rhizoctonia solani by Affecting Fungal Fatty Acid Metabolism and Destroying the Dynamic Equilibrium of Reactive Oxygen Species.

2 of 14

2.43

1.38

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22640

Tryptophan catabolic process, and Kynurenic acid metabolic process

5 of 10

2.97

5.28

1.65e-10

CL:22189

Mixed, incl. DapA-like, and D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

5 of 58

2.21

3.38

1.27e-07

CL:22283

Phosphoenolpyruvate carboxykinase, and Formate catabolic process

3 of 8

2.85

2.79

7.62e-06

CL:22642

Kynurenine 3-monooxygenase activity, and Kynurenic acid metabolic process

2 of 5

2.87

1.53

0.0017

CL:22198

Isocitrate lyase, and Dihydrodipicolinate synthetase family

2 of 22

2.23

0.92

0.0201

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00630

Glyoxylate and dicarboxylate metabolism

7 of 162

1.91

3.95

1.14e-10

map00380

Tryptophan metabolism

5 of 158

1.77

2.51

1.04e-06

map01200

Carbon metabolism

4 of 415

1.26

1.01

0.0020

map01100

Metabolic pathways

11 of 5771

0.55

0.48

4.56e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71240

Tryptophan catabolism

4 of 75

2.0

2.06

6.44e-05

MAP-71291

Metabolism of amino acids and derivatives

5 of 650

1.16

0.82

0.0063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009514

Glyoxysome

2 of 6

2.79

1.13

0.0089

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0329

Glyoxylate bypass

2 of 2

3.27

1.88

0.00041

KW-0816

Tricarboxylic acid cycle

2 of 12

2.49

1.36

0.0031

KW-0464

Manganese

2 of 23

2.21

1.16

0.0067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01274

Malate synthase

2 of 2

3.27

1.33

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046363

Malate synthase, N-terminal and TIM-barrel domains

2 of 2

3.27

1.11

0.0103

IPR044856

Malate synthase, C-terminal superfamily

2 of 2

3.27

1.11

0.0103

IPR019830

Malate synthase, conserved site

2 of 2

3.27

1.11

0.0103

IPR011076

Malate synthase superfamily

2 of 2

3.27

1.11

0.0103

IPR006252

Malate synthase A

2 of 2

3.27

1.11

0.0103

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00835

Cupin

2 of 9

2.62

1.16

0.0077

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