fecR-3 protein (Caldithrix abyssi) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

fecR-3

FecR protein. (727 aa)

Predicted Functional Partners:

APF20286.1

0.741

Cabys_836

0.734

APF18849.1

0.700

APF20649.1

0.688

APF19122.1

0.686

APF19015.1

0.678

APF20259.1

0.677

APF20666.1

0.677

Cabys_133

0.676

APF18126.1

0.676

Your Current Organism:

Caldithrix abyssi

NCBI taxonomy Id: 880073
Other names: C. abyssi DSM 13497, Caldithrix abyssi DSM 13497, Caldithrix abyssi LF13, Caldithrix abyssi str. DSM 13497, Caldithrix abyssi strain DSM 13497

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APF18126.1	APF20666.1	Cabys_1377	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.758
APF18126.1	fecR-3	Cabys_1377	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.676
APF18849.1	APF20666.1	Cabys_2100	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.652
APF18849.1	fecR-3	Cabys_2100	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.700
APF19015.1	APF20666.1	Cabys_2266	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.745
APF19015.1	fecR-3	Cabys_2266	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.678
APF19122.1	APF20286.1	Cabys_2373	Cabys_3540	Por secretion system C-terminal sorting domain-containing protein.	Por secretion system C-terminal sorting domain-containing protein.	0.773
APF19122.1	APF20666.1	Cabys_2373	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.762
APF19122.1	fecR-3	Cabys_2373	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.686
APF20259.1	APF20666.1	Cabys_3513	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.714
APF20259.1	fecR-3	Cabys_3513	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.677
APF20286.1	APF19122.1	Cabys_3540	Cabys_2373	Por secretion system C-terminal sorting domain-containing protein.	Por secretion system C-terminal sorting domain-containing protein.	0.773
APF20286.1	APF20649.1	Cabys_3540	Cabys_3904	Por secretion system C-terminal sorting domain-containing protein.	Por secretion system C-terminal sorting domain-containing protein.	0.774
APF20286.1	APF20666.1	Cabys_3540	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.655
APF20286.1	Cabys_133	Cabys_3540	Cabys_133	Por secretion system C-terminal sorting domain-containing protein.	Por secretion system C-terminal sorting domain-containing protein.	0.761
APF20286.1	fecR-3	Cabys_3540	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.741
APF20649.1	APF20286.1	Cabys_3904	Cabys_3540	Por secretion system C-terminal sorting domain-containing protein.	Por secretion system C-terminal sorting domain-containing protein.	0.774
APF20649.1	APF20666.1	Cabys_3904	Cabys_3921	Por secretion system C-terminal sorting domain-containing protein.	Hypothetical protein.	0.721
APF20649.1	fecR-3	Cabys_3904	Cabys_2539	Por secretion system C-terminal sorting domain-containing protein.	FecR protein.	0.688
APF20666.1	APF18126.1	Cabys_3921	Cabys_1377	Hypothetical protein.	Por secretion system C-terminal sorting domain-containing protein.	0.758

page 1 of 3

Network Stats

number of nodes:

6

number of edges:

7

average node degree:

2.33

avg. local clustering coefficient:

0.811

expected number of edges:

5

PPI enrichment p-value:

0.259

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000463

Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

9 of 33

2.52

8.46

1.41e-18

GO:0042273

Ribosomal large subunit biogenesis

11 of 95

2.15

7.52

2.00e-20

GO:0006364

rRNA processing

11 of 321

1.62

3.79

2.06e-15

GO:0000466

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

5 of 68

1.95

2.85

5.04e-07

GO:0000054

Ribosomal subunit export from nucleus

3 of 37

1.99

1.59

0.00070

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043021

Ribonucleoprotein complex binding

4 of 72

1.83

1.54

0.00063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

9 of 43

2.4

7.88

5.23e-18

GO:0070545

PeBoW complex

3 of 3

3.08

3.37

7.12e-07

GO:0005730

Nucleolus

10 of 388

1.49

2.93

1.71e-12

GO:1990904

Ribonucleoprotein complex

10 of 663

1.26

1.96

2.52e-10

GO:0043232

Intracellular non-membrane-bounded organelle

11 of 1664

0.9

1.03

1.90e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8147

Preribosome, large subunit precursor, and Nop2p

9 of 31

2.55

8.59

1.03e-18

CL:8131

Ribosomal large subunit biogenesis, and Preribosome, large subunit precursor

10 of 92

2.12

6.77

4.00e-18

CL:8149

Preribosome, large subunit precursor, and Nop2p

6 of 20

2.56

5.73

4.82e-12

CL:8156

Preribosome, large subunit precursor

5 of 10

2.78

5.25

1.22e-10

CL:8166

PeBoW complex, and Pescadillo

4 of 5

2.99

4.4

7.81e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

3 of 138

1.42

0.72

0.0286

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

8 of 206

1.67

3.13

6.09e-10

MAP-8868773

rRNA processing in the nucleus and cytosol

8 of 213

1.66

3.09

6.09e-10

MAP-72312

rRNA processing

8 of 221

1.64

3.04

6.09e-10

MAP-8953854

Metabolism of RNA

9 of 853

1.11

1.37

2.31e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031981

Nuclear lumen

8 of 799

1.08

1.14

2.87e-05

GOCC:0005654

Nucleoplasm

4 of 383

1.1

0.58

0.0381

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0698

rRNA processing

3 of 27

2.13

1.74

0.00043

KW-0690

Ribosome biogenesis

3 of 31

2.07

1.72

0.00043

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