lpxK protein (Ketogulonicigenium vulgare) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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[Homology]

Score

lpxK

Tetraacyldisaccharide 4'-kinase. (322 aa)

Predicted Functional Partners:

EIO_1730

0.998

EIO_1559

0.997

EIO_2809

0.990

EIO_1858

0.908

EIO_0382

0.903

EIO_1561

0.903

EIO_1075

0.900

EIO_2256

0.871

EIO_2810

0.848

EIO_2808

0.842

Your Current Organism:

Ketogulonicigenium vulgare

NCBI taxonomy Id: 880591
Other names: K. vulgare Y25, Ketogulonicigenium vulgare Y25, Ketogulonicigenium vulgare str. Y25, Ketogulonicigenium vulgare strain Y25

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIO_0382	EIO_1075	EIO_0382	EIO_1075	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	0.989
EIO_0382	EIO_1559	EIO_0382	EIO_1559	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	lipid-A-disaccharide synthase.	0.904
EIO_0382	EIO_1561	EIO_0382	EIO_1561	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase.	0.990
EIO_0382	EIO_1730	EIO_0382	EIO_1730	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	RNA polymerase sigma factor.	0.794
EIO_0382	EIO_1858	EIO_0382	EIO_1858	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	KpsF/GutQ family protein.	0.868
EIO_0382	EIO_2256	EIO_0382	EIO_2256	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	Lipid A biosynthesis lauroyl acyltransferase, putative.	0.822
EIO_0382	lpxK	EIO_0382	EIO_2807	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	Tetraacyldisaccharide 4'-kinase.	0.903
EIO_1075	EIO_0382	EIO_1075	EIO_0382	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	0.989
EIO_1075	EIO_1559	EIO_1075	EIO_1559	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	lipid-A-disaccharide synthase.	0.992
EIO_1075	EIO_1561	EIO_1075	EIO_1561	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase.	0.981
EIO_1075	EIO_1730	EIO_1075	EIO_1730	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	RNA polymerase sigma factor.	0.765
EIO_1075	EIO_1858	EIO_1075	EIO_1858	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	KpsF/GutQ family protein.	0.849
EIO_1075	EIO_2256	EIO_1075	EIO_2256	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	Lipid A biosynthesis lauroyl acyltransferase, putative.	0.820
EIO_1075	lpxK	EIO_1075	EIO_2807	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	Tetraacyldisaccharide 4'-kinase.	0.900
EIO_1559	EIO_0382	EIO_1559	EIO_0382	lipid-A-disaccharide synthase.	UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase.	0.904
EIO_1559	EIO_1075	EIO_1559	EIO_1075	lipid-A-disaccharide synthase.	UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase.	0.992
EIO_1559	EIO_1561	EIO_1559	EIO_1561	lipid-A-disaccharide synthase.	acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase.	0.996
EIO_1559	EIO_1730	EIO_1559	EIO_1730	lipid-A-disaccharide synthase.	RNA polymerase sigma factor.	0.797
EIO_1559	EIO_1858	EIO_1559	EIO_1858	lipid-A-disaccharide synthase.	KpsF/GutQ family protein.	0.875
EIO_1559	EIO_2256	EIO_1559	EIO_2256	lipid-A-disaccharide synthase.	Lipid A biosynthesis lauroyl acyltransferase, putative.	0.873

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.813

expected number of edges:

13

PPI enrichment p-value:

6.67e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000105

Histidine biosynthetic process

4 of 11

2.1

2.13

5.87e-05

GO:0008652

Cellular amino acid biosynthetic process

5 of 134

1.11

0.78

0.0067

GO:0006520

Cellular amino acid metabolic process

6 of 216

0.98

0.72

0.0051

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29544475

(2018) Specific features of L-histidine production by Escherichia coli concerned with feedback control of AICAR formation and inorganic phosphatemetal transport.

3 of 13

1.9

1.41

0.0015

PMID:30962820

(2019) Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum.

3 of 19

1.74

1.3

0.0020

PMID:29075239

(2017) Insight of Genus Corynebacterium: Ascertaining the Role of Pathogenic and Non-pathogenic Species.

2 of 14

1.7

0.69

0.0448

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1868

Mixed, incl. Polyol metabolic process, and DoxX

6 of 11

2.28

4.32

1.14e-09

CL:1871

Mixed, incl. DoxX, and RNA polymerase sigma-70 like

5 of 5

2.54

4.21

7.44e-09

CL:679

Histidine biosynthetic process

3 of 5

2.32

2.03

0.00014

CL:653

Aromatic amino acid family biosynthetic process, and Histidine biosynthetic process

4 of 21

1.82

1.86

0.00010

CL:585

Mixed, incl. Aromatic amino acid family biosynthetic process, and Histidine biosynthetic process

5 of 55

1.5

1.58

0.00010

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

bly00340

Histidine metabolism

4 of 34

1.61

1.53

0.00031

bly00400

Phenylalanine, tyrosine and tryptophan biosynthesis

3 of 26

1.6

1.2

0.0024

bly01230

Biosynthesis of amino acids

6 of 172

1.08

1.0

0.00031

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0368

Histidine biosynthesis

3 of 12

1.94

1.44

0.0014

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