Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cbiKpChelatase, putative; Catalyzes the insertion of Co(2+) into sirohydrochlorin. To a lesser extent, is also able to insert Fe(2+) into sirohydrochlorin, yielding siroheme. Its periplasmic location means that it cannot participate in cobalamin biosynthesis and its genomic environment suggests it is likely to be associated with a heme or metal transport system. (297 aa)    
Predicted Functional Partners:
cobI
Precorrin-2 C20-methyltransferase; Identified by similarity to SP:Q05593; match to protein family HMM PF00590; match to protein family HMM TIGR01467; Belongs to the precorrin methyltransferase family.
 
 0.999
cobM
Precorrin-4 C11-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01465.
  
 0.982
cbiG
Cobalamin biosynthesis protein CbiG; Identified by similarity to SP:Q05631; match to protein family HMM PF01890.
 
  
 0.935
DVU_1463
Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470.
    
 0.913
cbiKc
Heme-binding protein, putative; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. To a lesser extent, is also able to insert Fe(2+) into sirohydrochlorin, yielding siroheme.
 
  
 
0.910
cobJ
Precorrin-3b C17-methyltransferase; Identified by similarity to SP:P21640; match to protein family HMM PF00590; match to protein family HMM TIGR01466.
 
  
 0.885
cbiD
Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.850
cobH
precorrin-8X methylmutase; Identified by similarity to GP:15826199; match to protein family HMM PF02570.
 
  
 0.806
DVU_0647
Iron compound ABC transporter, periplasmic iron compount-binding protein, putative; Identified by similarity to OMNI:DRB0007; match to protein family HMM PF01497.
     
 0.801
cobL
precorrin-6Y C5,15-methyltransferase (decarboxylating); Identified by similarity to SP:P21921; match to protein family HMM PF00590; match to protein family HMM TIGR01468.
 
  
 0.800
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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