Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
DVU_0734Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP:12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469. (503 aa)    
Predicted Functional Partners:
DVU_1463
Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470.
 
 0.999
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
hemB
Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family.
 
 0.996
cobI
Precorrin-2 C20-methyltransferase; Identified by similarity to SP:Q05593; match to protein family HMM PF00590; match to protein family HMM TIGR01467; Belongs to the precorrin methyltransferase family.
 
 
 0.965
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.958
DVU_1566
Phosphoadenosine phosphosulfate reductase, putative; Identified by match to protein family HMM PF01507.
 
  
 0.924
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P30949; match to protein family HMM PF00202; match to protein family HMM TIGR00713; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
  
 0.896
ccmC
Cytochrome c-type biogenesis protein CcmC; Identified by similarity to SP:P33929; match to protein family HMM PF01578.
  
  
 0.892
DVU_1462
Cytochrome c assembly protein, putative; Identified by match to protein family HMM PF01578.
  
  
 0.892
DVU_1597
Sulfite reductase, assimilatory-type; This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
  
 0.884
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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