STRINGSTRING
hisD protein (Desulfovibrio vulgaris Hildenborough) - STRING interaction network
"hisD" - Histidinol dehydrogenase in Desulfovibrio vulgaris Hildenborough
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (436 aa)    
Predicted Functional Partners:
hisF
Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit; Belongs to the HisA/HisF family (259 aa)
 
  0.997
hisB
Imidazoleglycerol-phosphate dehydratase; Identified by similarity to SP-O34683; match to protein family HMM PF00475 (198 aa)
 
  0.995
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Long subfamily (293 aa)
 
  0.993
hisC
Histidinol-phosphate aminotransferase; Identified by similarity to SP-P17731; match to protein family HMM PF00155; match to protein family HMM TIGR01141 (373 aa)
 
  0.989
hisI
Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP (126 aa)
 
   
  0.985
hisA
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Identified by similarity to SP-O35006; match to protein family HMM PF00977 (249 aa)
   
  0.978
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (213 aa)
 
   
  0.977
DVU_2490
Histidinol phosphatase, putative; Identified by similarity to SP-O34411; match to protein family HMM PF02231; match to protein family HMM PF02811; match to protein family HMM TIGR01856 (274 aa)
 
 
  0.926
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Identified by similarity to SP-Q59566; match to protein family HMM PF01259; match to protein family HMM TIGR00081; Belongs to the SAICAR synthetase family (298 aa)
   
 
  0.922
DVU_1059
annotation not available (390 aa)
 
 
  0.840
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris Hildenborough, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
Server load: low (23%) [HD]