node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DVU_0964 | queF | DVU_0964 | DVU_0963 | Identified by match to protein family HMM PF00208. | GTP cyclohydrolase I family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.452 |
DVU_1352 | DVU_2657 | DVU_1352 | DVU_2657 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | 0.923 |
DVU_1352 | guaA | DVU_1352 | DVU_1043 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.492 |
DVU_1352 | queC | DVU_1352 | DVU_2659 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.859 |
DVU_1352 | queE | DVU_1352 | DVU_2658 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.980 |
DVU_1352 | queF | DVU_1352 | DVU_0963 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | GTP cyclohydrolase I family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.756 |
DVU_2657 | DVU_1352 | DVU_2657 | DVU_1352 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | 0.923 |
DVU_2657 | guaA | DVU_2657 | DVU_1043 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.500 |
DVU_2657 | queC | DVU_2657 | DVU_2659 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.934 |
DVU_2657 | queE | DVU_2657 | DVU_2658 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.991 |
DVU_2657 | queF | DVU_2657 | DVU_0963 | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | GTP cyclohydrolase I family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.756 |
guaA | DVU_1352 | DVU_1043 | DVU_1352 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | 0.492 |
guaA | DVU_2657 | DVU_1043 | DVU_2657 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 6-pyruvoyl tetrahydrobiopterin synthase, putative; Identified by match to protein family HMM PF01242. | 0.500 |
guaA | queE | DVU_1043 | DVU_2658 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.583 |
guaA | queF | DVU_1043 | DVU_0963 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | GTP cyclohydrolase I family protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.583 |
guaA | ribAB | DVU_1043 | DVU_1199 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.733 |
guaA | ribD | DVU_1043 | DVU_1201 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.623 |
guaA | tgt | DVU_1043 | DVU_0726 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...] | 0.777 |
queA | queC | DVU_3351 | DVU_2659 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.564 |
queA | queE | DVU_3351 | DVU_2658 | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.400 |