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nth protein (Desulfovibrio vulgaris Hildenborough) - STRING interaction network
"nth" - Endonuclease III in Desulfovibrio vulgaris Hildenborough
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3’ to the AP site by a beta-elimination, leaving a 3’-terminal unsaturated sugar and a product with a terminal 5’-phosphate (285 aa)    
Predicted Functional Partners:
xth
Exodeoxyribonuclease III; Identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633 (257 aa)
 
  0.932
DVU_2795
Electron transport complex subunit E; Part of a membrane complex involved in electron transport (223 aa)
 
   
  0.889
mutM
Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3’- and 5’-phosphates (365 aa)
   
   
  0.860
DVU_0991
Uncharacterized protein; Identified by similarity to OMNI-NTL01MM1967 (272 aa)
              0.855
polA
DNA polymerase I; Identified by similarity to SP-P00582; match to protein family HMM PF00476; match to protein family HMM PF01367; match to protein family HMM PF02739; match to protein family HMM TIGR00593 (1015 aa)
   
 
  0.832
dinP
DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3’-5’ exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (386 aa)
   
 
  0.798
DVU_1186
MazG family protein; Identified by similarity to OMNI-VC2450; match to protein family HMM PF03819; match to protein family HMM TIGR00444 (267 aa)
         
  0.791
rhlE
ATP-dependent RNA helicase RhlE; Identified by similarity to SP-P25888; match to protein family HMM PF00270; match to protein family HMM PF00271 (462 aa)
   
   
  0.767
DVU_0989
Periplasmic divalent cation tolerance protein cutA, putative; Identified by similarity to SP-P36654; match to protein family HMM PF03091 (146 aa)
   
        0.704
DVU_0988
Carbohydrate kinase, PfkB family; Identified by match to protein family HMM PF00294 (308 aa)
              0.689
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris Hildenborough, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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