STRINGSTRING
cobU protein (Desulfovibrio vulgaris Hildenborough) - STRING interaction network
"cobU" - Bifunctional adenosylcobalamin biosynthesis protein in Desulfovibrio vulgaris Hildenborough
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cobUBifunctional adenosylcobalamin biosynthesis protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate; Belongs to the CobU/CobP family (178 aa)    
Predicted Functional Partners:
cobS
Adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5’-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5’-phosphate; Belongs to the CobS family (245 aa)
 
 
  0.994
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (543 aa)
   
  0.993
cobT
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5’-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (357 aa)
   
  0.991
cobD
Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (320 aa)
 
 
  0.990
cobO
Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids (167 aa)
 
 
  0.982
cobM
Precorrin-4 C11-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01465 (257 aa)
   
  0.905
DVU_2037
CobS protein, putative; Identified by similarity to SP-P29933 (324 aa)
         
    0.900
cobL
Precorrin-6Y C5,15-methyltransferase (Decarboxylating); Identified by similarity to SP-P21921; match to protein family HMM PF00590; match to protein family HMM TIGR01468 (486 aa)
 
   
  0.877
DVU_0734
Uroporphyrinogen III synthase/methyltransferase; Identified by similarity to GP-12655814; match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01369; match to protein family HMM TIGR01469 (503 aa)
 
   
  0.756
cobB-2
Cobyrinate a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family (607 aa)
 
   
  0.744
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris Hildenborough, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
Server load: low (15%) [HD]