node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DVU_2147 | gcvPA | DVU_2147 | DVU_1425 | L-serine dehydratase, putative; Identified by match to protein family HMM PF03313; match to protein family HMM PF03315. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. | 0.497 |
DVU_2147 | gcvPB | DVU_2147 | DVU_1424 | L-serine dehydratase, putative; Identified by match to protein family HMM PF03313; match to protein family HMM PF03315. | Glycine cleavage system P protein, subunit 2; Identified by similarity to SP:P54377; Belongs to the GcvP family. | 0.500 |
DVU_2147 | gcvT | DVU_2147 | DVU_1684 | L-serine dehydratase, putative; Identified by match to protein family HMM PF03313; match to protein family HMM PF03315. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.577 |
DVU_2147 | glyA | DVU_2147 | DVU_1203 | L-serine dehydratase, putative; Identified by match to protein family HMM PF03313; match to protein family HMM PF03315. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the SHMT family. | 0.970 |
DVU_3206 | folD | DVU_3206 | DVU_0323 | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.966 |
DVU_3206 | gcvPB | DVU_3206 | DVU_1424 | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. | Glycine cleavage system P protein, subunit 2; Identified by similarity to SP:P54377; Belongs to the GcvP family. | 0.529 |
DVU_3206 | gcvT | DVU_3206 | DVU_1684 | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.933 |
DVU_3206 | glyA | DVU_3206 | DVU_1203 | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the SHMT family. | 0.982 |
DVU_3206 | purN | DVU_3206 | DVU_0736 | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.998 |
fmt | folD | DVU_3365 | DVU_0323 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.977 |
fmt | gcvH | DVU_3365 | DVU_1426 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.440 |
fmt | gcvT | DVU_3365 | DVU_1684 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.945 |
fmt | glyA | DVU_3365 | DVU_1203 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the SHMT family. | 0.969 |
fmt | purN | DVU_3365 | DVU_0736 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
folD | DVU_3206 | DVU_0323 | DVU_3206 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase, putative; Identified by similarity to SP:P12048; match to protein family HMM PF01808. | 0.966 |
folD | fmt | DVU_0323 | DVU_3365 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.977 |
folD | gcvH | DVU_0323 | DVU_1426 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.776 |
folD | gcvPB | DVU_0323 | DVU_1424 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system P protein, subunit 2; Identified by similarity to SP:P54377; Belongs to the GcvP family. | 0.751 |
folD | gcvT | DVU_0323 | DVU_1684 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; Identified by match to protein family HMM PF01571; match to protein family HMM TIGR00528. | 0.972 |
folD | glyA | DVU_0323 | DVU_1203 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism; Belongs to the SHMT family. | 0.988 |