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ilvC protein (Desulfovibrio vulgaris Hildenborough) - STRING interaction network
"ilvC" - Ketol-acid reductoisomerase in Desulfovibrio vulgaris Hildenborough
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (331 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Identified by similarity to SP-P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family (554 aa)
 
  0.999
ilvB-2
Acetolactate synthase; Identified by similarity to SP-P00893; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118 (563 aa)
 
 
  0.995
ilvN-2
Acetolactate synthase, small subunit; Identified by similarity to SP-P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119 (162 aa)
 
  0.994
ilvB-1
Acetolactate synthase; Identified by similarity to SP-P08142; match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR00118 (563 aa)
 
 
  0.987
ilvN-1
Acetolactate synthase, small subunit; Identified by similarity to SP-P37252; match to protein family HMM PF01842; match to protein family HMM TIGR00119 (159 aa)
 
  0.985
DVU_0361
Acetolactate synthase III, small subunit, putative; Identified by match to protein family HMM PF01842 (107 aa)
   
  0.968
DVU_3293
Thiamine pyrophosphate-requiring enzyme; Identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; Belongs to the TPP enzyme family (547 aa)
 
 
  0.964
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (167 aa)
 
   
  0.892
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N’-(5’-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity; Belongs to the ATP phosphoribosyltransferase family. Long subfamily (293 aa)
   
   
  0.879
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily (419 aa)
 
   
  0.852
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris Hildenborough, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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