Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (120 aa)    
Predicted Functional Partners:
hypB
Hydrogenase accessory protein HypB; Identified by similarity to SP:P24190; match to protein family HMM PF01495; match to protein family HMM TIGR00073.
 
 
 0.987
cooF
Iron-sulfur protein CooF; Identified by similarity to SP:P31894; match to protein family HMM PF00037.
  
  
 0.974
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P42034; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
  
 0.929
hypD
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924.
 
  
 0.927
hypC
Hydrogenase assembly chaperone hypC/hupF; Identified by similarity to GP:15430693; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
  
 0.924
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.913
DVU_2291
Carbon monoxide-induced hydrogenase CooH, putative; Identified by similarity to SP:P31895; match to protein family HMM PF00346.
  
 
 0.849
DVU_2288
Hydrogenase, CooL subunit, putative; Identified by similarity to GP:1515468; match to protein family HMM PF01058.
  
  
 0.846
DVU_2290
Hydrogenase, CooU subunit, putative; Identified by similarity to GP:1515470; match to protein family HMM PF00329.
  
  
 0.824
DVU_2289
Hydrogenase, CooX subunit, putative; Identified by match to protein family HMM PF00037.
  
  
 0.813
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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