STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (120 aa)    
Predicted Functional Partners:
hypB
Hydrogenase accessory protein HypB; Identified by similarity to SP:P24190; match to protein family HMM PF01495; match to protein family HMM TIGR00073.
 
 
 0.985
cooF
Iron-sulfur protein CooF; Identified by similarity to SP:P31894; match to protein family HMM PF00037.
  
  
 0.967
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.915
hypD
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924.
 
  
 0.911
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P42034; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
  
 0.905
hypC
Hydrogenase assembly chaperone hypC/hupF; Identified by similarity to GP:15430693; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
  
 0.889
DVU_2291
Carbon monoxide-induced hydrogenase CooH, putative; Identified by similarity to SP:P31895; match to protein family HMM PF00346.
  
 
 0.864
DVU_2288
Hydrogenase, CooL subunit, putative; Identified by similarity to GP:1515468; match to protein family HMM PF01058.
  
  
 0.851
DVU_2289
Hydrogenase, CooX subunit, putative; Identified by match to protein family HMM PF00037.
  
  
 0.824
DVU_2290
Hydrogenase, CooU subunit, putative; Identified by similarity to GP:1515470; match to protein family HMM PF00329.
  
    0.824
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.