| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DVU_0299 | DVU_2947 | DVU_0299 | DVU_2947 | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | 0.903 |
| DVU_0299 | dut | DVU_0299 | DVU_2348 | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.925 |
| DVU_0299 | ndk | DVU_0299 | DVU_2333 | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.908 |
| DVU_1202 | dut | DVU_1202 | DVU_2348 | Identified by match to protein family HMM PF00383. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.948 |
| DVU_1202 | surE | DVU_1202 | DVU_2142 | Identified by match to protein family HMM PF00383. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| DVU_1202 | thyX | DVU_1202 | DVU_2254 | Identified by match to protein family HMM PF00383. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.928 |
| DVU_1202 | tmk | DVU_1202 | DVU_2140 | Identified by match to protein family HMM PF00383. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.924 |
| DVU_2947 | DVU_0299 | DVU_2947 | DVU_0299 | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | 0.903 |
| DVU_2947 | dut | DVU_2947 | DVU_2348 | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.917 |
| DVU_2947 | ndk | DVU_2947 | DVU_2333 | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.908 |
| DVU_3154 | dut | DVU_3154 | DVU_2348 | HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.960 |
| DVU_3154 | ndk | DVU_3154 | DVU_2333 | HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.933 |
| DVU_3154 | surE | DVU_3154 | DVU_2142 | HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.902 |
| coaBC | dut | DVU_3353 | DVU_2348 | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.963 |
| dnaN | dut | DVU_0002 | DVU_2348 | DNA polymerase III, beta subunit; Identified by match to protein family HMM PF00712; match to protein family HMM PF02768; match to protein family HMM TIGR00663. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.844 |
| dut | DVU_0299 | DVU_2348 | DVU_0299 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | 0.925 |
| dut | DVU_1202 | DVU_2348 | DVU_1202 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Identified by match to protein family HMM PF00383. | 0.948 |
| dut | DVU_2947 | DVU_2348 | DVU_2947 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Anaerobic ribonucleoside-triphosphate reductase, putative; Identified by similarity to GP:4127320; match to protein family HMM PF03477. | 0.917 |
| dut | DVU_3154 | DVU_2348 | DVU_3154 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.960 |
| dut | coaBC | DVU_2348 | DVU_3353 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.963 |
