STRINGSTRING
birA protein (Desulfovibrio vulgaris Hildenborough) - STRING interaction network
"birA" - Bifunctional ligase/repressor BirA in Desulfovibrio vulgaris Hildenborough
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
birABifunctional ligase/repressor BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor (330 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family (310 aa)
 
 
  0.991
DVU_1767
Radical SAM domain protein; Identified by match to protein family HMM PF04055 (322 aa)
   
 
  0.962
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily (542 aa)
 
     
  0.944
bioD
ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (246 aa)
 
   
  0.893
bioF
8-amino-7-oxononanoate synthase; Identified by similarity to SP-P22806 (424 aa)
 
   
  0.880
DVU_1835
Biotin--acetyl-CoA-carboxylase ligase; Identified by match to protein family HMM PF03099; match to protein family HMM TIGR00121 (304 aa)
 
   
0.855
DVU_2889
Identified by match to protein family HMM PF02632 (182 aa)
 
     
  0.846
nadE
Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source (559 aa)
   
   
  0.826
DVU_2224
Uncharacterized protein; Identified by Glimmer2; putative (216 aa)
     
 
  0.817
DVU_2563
Beta-ketoacyl synthase, putative; Identified by match to protein family HMM PF00109; match to protein family HMM PF02801; Belongs to the beta-ketoacyl-ACP synthases family (482 aa)
 
   
  0.814
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris Hildenborough, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
Server load: low (17%) [HD]