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leuD protein (Desulfovibrio vulgaris Hildenborough) - STRING interaction network
"leuD" - 3-isopropylmalate dehydratase small subunit in Desulfovibrio vulgaris Hildenborough
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (167 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily (419 aa)
  0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily (357 aa)
 
  0.999
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily (509 aa)
 
 
  0.998
DVU_1914
2-isopropylmalate synthase/homocitrate synthase family protein; Identified by match to protein family HMM PF00682; match to protein family HMM TIGR00977; Belongs to the alpha-IPM synthase/homocitrate synthase family (538 aa)
   
 
  0.960
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate; Belongs to the ketol-acid reductoisomerase family (331 aa)
 
   
  0.892
ilvD
Dihydroxy-acid dehydratase; Identified by similarity to SP-P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family (554 aa)
 
   
  0.876
DVU_2984
Uncharacterized protein; Identified by similarity to OMNI-NTL01AA00614; match to protein family HMM PF01937 (335 aa)
              0.845
ldh
L-lactate dehydrogenase; Identified by similarity to SP-P00345; match to protein family HMM PF00056; match to protein family HMM PF02866; match to protein family HMM TIGR01771; Belongs to the LDH/MDH superfamily. LDH family (309 aa)
       
    0.839
DVU_2824
Formate acetyltransferase; Identified by match to protein family HMM PF01228; match to protein family HMM PF02901 (828 aa)
       
  0.815
DVU_2272
Formate acetyltransferase, putative; Identified by similarity to SP-P32674; match to protein family HMM PF01228; match to protein family HMM PF02901 (817 aa)
       
  0.815
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris Hildenborough, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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