STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
hypF[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (839 aa)    
Predicted Functional Partners:
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P42034; match to protein family HMM PF00586; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
 
 0.995
hypC
Hydrogenase assembly chaperone hypC/hupF; Identified by similarity to GP:15430693; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
 
 0.964
hypD
Hydrogenase expression/formation protein HypD; Identified by similarity to SP:P24192; match to protein family HMM PF01924.
 
  
 0.962
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.915
hypB
Hydrogenase accessory protein HypB; Identified by similarity to SP:P24190; match to protein family HMM PF01495; match to protein family HMM TIGR00073.
 
   
 0.897
DVU_1919
Hydrogenase expression/formation protein, putative; Identified by match to protein family HMM PF01750; match to protein family HMM TIGR00072.
 
  
 0.770
hysA
Periplasmic [NiFeSe] hydrogenase, large subunit, selenocysteine-containing; Selenoprotein; identified by match to protein family HMM PF00374.
 
 
 
 0.759
hypA1
Hydrogenase nickel insertion protein HypA, putative; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.690
acyP
Acylphosphatase; Identified by match to protein family HMM PF00708.
     
 0.657
poR
Pyruvate-ferredoxin oxidoreductase; Identified by similarity to GP:1770208; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855.
  
  
 0.622
Your Current Organism:
Desulfovibrio vulgaris Hildenborough
NCBI taxonomy Id: 882
Other names: D. vulgaris str. Hildenborough, Desulfovibrio vulgaris (STRAIN HILDENBOROUGH), Desulfovibrio vulgaris ATCC 29579, Desulfovibrio vulgaris str. Hildenborough, Desulfovibrio vulgaris subsp. vulgaris (strain Hildenborough), Desulfovibrio vulgaris subsp. vulgaris ATCC 29579, Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
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