STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
CBW75585.1Acetaldehyde dehydrogenase (EC 1.2.1.10); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (320 aa)    
Predicted Functional Partners:
CBW75584.1
4-hydroxy-2-oxovalerate aldolase (EC 4.1.3.39); Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family.
 0.999
leuA
2-isopropylmalate synthase (EC 2.3.3.13); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 0.978
leuA-2
2-isopropylmalate synthase (EC 2.3.3.13); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.971
CBW75587.1
2-oxopent-4-enoate hydratase (EC 4.2.1.80); COG: 2-keto-4-pentenoate hydratase; Pfam: Hydratase/decarboxylase::PF01689.
  
 0.962
CBW75586.1
4-oxalocrotonate decarboxylase (EC 4.1.1.77); COG: 2-keto-4-pentenoate hydratase; Pfam: Hydratase/decarboxylase::PF01689.
  
 0.958
acsA
Acetyl-coenzyme A synthetase (EC 6.2.1.1); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
     
 0.905
CBW73887.1
Biotin carboxyl carrier protein of acetyl-CoA carboxylase (EC 6.4.1.2); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
     
 0.902
CBW76071.1
3-ketoacyl-CoA thiolase (EC 2.3.1.16); COG: Acetyl-CoA acetyltransferase; Pfam: Thiolase, C-terminal domain::PF02803<br>Thiolase, N-terminal domain::PF00108; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.901
CBW74893.1
Acetyl-CoA acetyltransferase (EC 2.3.1.9); COG: Acetyl-CoA acetyltransferase; Pfam: Thiolase, C-terminal domain::PF02803<br>Thiolase, N-terminal domain::PF00108; Belongs to the thiolase-like superfamily. Thiolase family.
     
 0.901
accD
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC 6.4.1.2); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.
     
  0.900
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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