STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBW73814.1NADP-dependent malic enzyme (EC 1.1.1.40); COG: Malic enzyme; Pfam: Malic enzyme, NAD binding domain::PF03949<br>Phosphate acetyl/butaryl transferase::PF01515<br>Malic enzyme, N-terminal domain::PF00390; Belongs to the malic enzymes family. (792 aa)    
Predicted Functional Partners:
CBW75936.1
Pyruvate kinase (EC 2.7.1.40); COG: Pyruvate kinase; Pfam: Pyruvate kinase, alpha/beta domain::PF02887<br>Pyruvate kinase, barrel domain::PF00224; Belongs to the pyruvate kinase family.
  
 0.965
mdh
Malate dehydrogenase (EC 1.1.1.37); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.964
fumC
Aldose 1-dehydrogenase (EC 1.1.1.121) / Fumarate hydratase class II (EC 4.2.1.2); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.961
CBW75398.1
Fumarate hydratase (EC 4.2.1.2); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
 
 
 0.959
CBW75503.1
Pyruvate dehydrogenase E1 component (EC 1.2.4.1); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 
 0.948
CBW75040.1
Phosphoenolpyruvate synthase (EC 2.7.9.2); COG: Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Pfam: PEP-utilising enzyme, mobile domain::PF00391<br>PEP-utilising enzyme, TIM barrel domain::PF02896<br>Pyruvate phosphate dikinase, PEP/pyruvate binding domain::PF01326.
  
 
 0.943
CBW73901.1
NADP-dependent malic enzyme (EC 1.1.1.40); COG: Malic enzyme; Pfam: Malic enzyme, NAD binding domain::PF03949<br>Phosphate acetyl/butaryl transferase::PF01515<br>Malic enzyme, N-terminal domain::PF00390.
 
 
0.940
CBW75613.1
Citrate synthase (EC 2.3.3.1); COG: Citrate synthase; Pfam: Citrate synthase::PF00285; Belongs to the citrate synthase family.
  
 0.924
CBW73954.1
(S)-2-hydroxy-acid oxidase chain D (EC 1.1.3.15); COG: FAD/FMN-containing dehydrogenases; Pfam: FAD linked oxidases, C-terminal domain::PF02913<br>FAD binding domain::PF01565.
  
 
 0.918
CBW75501.1
Dihydrolipoamide dehydrogenase (EC 1.8.1.4); COG: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes; Pfam: Pyridine nucleotide-disulphide oxidoreductase::PF00070<br>Pyridine nucleotide-disulphide oxidoreductase::PF07992<br>Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain::PF02852<br>Biotin-requiring enzyme::PF00364.
  
  
 0.914
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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