STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gyrBDNA gyrase subunit B (EC 5.99.1.3); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...] (843 aa)    
Predicted Functional Partners:
parC
Topoisomerase IV subunit A (EC 5.99.1.-); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.
 
 0.974
gyrA
DNA gyrase subunit A (EC 5.99.1.3); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...]
 
 0.973
CBW73529.1
DNA polymerase III, beta chain (EC 2.7.7.7); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...]
 
 0.968
CBW76033.1
4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262); COG: Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family.
 
      0.814
CBW76034.1
4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262); COG: Pyridoxal phosphate biosynthesis protein; Pfam: Pyridoxal phosphate biosynthetic protein PdxA::PF04166; Belongs to the PdxA family.
 
      0.788
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
 0.782
polA
DNA polymerase I (EC 2.7.7.7); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 
 0.604
CBW74542.1
DNA-directed RNA polymerase beta chain (EC 2.7.7.6); COG: DNA-directed RNA polymerase, beta subunit/140 kD subunit; Pfam: RNA polymerase Rpb2, domain 6::PF00562<br>RNA polymerase Rpb2, domain 7::PF04560.
  
  
 0.552
secA
Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.
  
   
 0.551
pheT
Phenylalanyl-tRNA synthetase beta chain (EC 6.1.1.20); COG: Phenylalanyl-tRNA synthetase beta subunit; Pfam: B3/4 domain::PF03483<br>Ferredoxin-fold anticodon binding domain::PF03147<br>Putative tRNA binding domain::PF01588<br>tRNA synthetase B5 domain::PF03484.
  
  
 0.532
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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