STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
glnEGlutamate-ammonia-ligase adenylyltransferase (EC 2.7.7.42); Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the [...] (956 aa)    
Predicted Functional Partners:
CBW75517.1
Glutamine synthetase (EC 6.3.1.2); COG: Glutamine synthetase; Pfam: Glutamine synthetase, catalytic domain::PF00120<br>Glutamine synthetase, beta-Grasp domain::PF03951.
 
  
 0.776
glnD
[protein-PII] uridylyltransferase (EC 2.7.7.59); Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.764
CBW73959.1
Carbon-nitrogen hydrolase family protein; COG: Predicted amidohydrolase; Pfam: Carbon-nitrogen hydrolase::PF00795.
 
   
 0.683
CBW73960.1
Hypothetical protein; COG: Predicted membrane protein.
 
     0.663
CBW74610.1
Glutamate synthase [NADPH] large chain (EC 1.4.1.13); COG: Glutamate synthase domain 1; Pfam: Glutamine amidotransferases class-II::PF00310<br>GXGXG motif::PF01493<br>Glutamate synthase central domain::PF04898<br>Conserved region in glutamate synthase::PF01645.
     
 0.553
CBW74918.1
Thioredoxin peroxidase (EC 1.11.1.15); COG: Peroxiredoxin; Pfam: AhpC/TSA family::PF00578<br>Redoxin::PF08534.
      0.510
CBW73958.1
Microcin-processing peptidase 2 (TldD); COG: Predicted Zn-dependent proteases and their inactivated homologs; Pfam: Putative modulator of DNA gyrase::PF01523.
  
    0.501
nadE
Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
     
 0.478
CBW76130.1
Tetratricopeptide repeat family protein; COG: FOG: TPR repeat; Pfam: Tetratricopeptide repeat::PF07719<br>Tetratricopeptide repeat::PF07721.
  
     0.419
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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