node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CBW74267.1 | CBW75599.1 | RBRH_01754 | RBRH_00189 | Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | 0.930 |
CBW74267.1 | gcvT | RBRH_01754 | RBRH_00846 | Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family. | Aminomethyltransferase (EC 2.1.2.10); The glycine cleavage system catalyzes the degradation of glycine. | 0.923 |
CBW74267.1 | glyA | RBRH_01754 | RBRH_01534 | Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase (EC 2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.938 |
CBW74267.1 | thyA | RBRH_01754 | RBRH_01755 | Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family. | Thymidylate synthase (EC 2.1.1.45); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
CBW75599.1 | CBW74267.1 | RBRH_00189 | RBRH_01754 | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family. | 0.930 |
CBW75599.1 | folD | RBRH_00189 | RBRH_03810 | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.524 |
CBW75599.1 | glyA | RBRH_00189 | RBRH_01534 | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase (EC 2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.709 |
CBW75599.1 | surE | RBRH_00189 | RBRH_03744 | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | Acid phosphatase surE (EC 3.1.3.2); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.400 |
CBW75599.1 | thyA | RBRH_00189 | RBRH_01755 | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase (EC 2.1.1.45); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.860 |
CBW76311.1 | folD | RBRH_02728 | RBRH_03810 | Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.937 |
CBW76311.1 | gcvT | RBRH_02728 | RBRH_00846 | Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase (EC 2.1.2.10); The glycine cleavage system catalyzes the degradation of glycine. | 0.938 |
CBW76311.1 | glyA | RBRH_02728 | RBRH_01534 | Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase (EC 2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.947 |
CBW76311.1 | thyA | RBRH_02728 | RBRH_01755 | Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase (EC 2.1.1.45); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.930 |
dut | surE | RBRH_00940 | RBRH_03744 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Acid phosphatase surE (EC 3.1.3.2); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
dut | thyA | RBRH_00940 | RBRH_01755 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase (EC 2.1.1.45); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.964 |
dut | tmk | RBRH_00940 | RBRH_01583 | Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase (EC 2.7.4.9); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.943 |
folD | CBW75599.1 | RBRH_03810 | RBRH_00189 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family. | 0.524 |
folD | CBW76311.1 | RBRH_03810 | RBRH_02728 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.937 |
folD | gcvT | RBRH_03810 | RBRH_00846 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase (EC 2.1.2.10); The glycine cleavage system catalyzes the degradation of glycine. | 0.957 |
folD | glyA | RBRH_03810 | RBRH_01534 | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase (EC 2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |