STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
thyAThymidylate synthase (EC 2.1.1.45); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (278 aa)    
Predicted Functional Partners:
CBW74267.1
Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family.
 
 
 0.999
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC 3.6.1.23); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
  
 0.964
tmk
Thymidylate kinase (EC 2.7.4.9); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.941
glyA
Serine hydroxymethyltransferase (EC 2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.938
gcvT
Aminomethyltransferase (EC 2.1.2.10); The glycine cleavage system catalyzes the degradation of glycine.
    
 0.931
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.931
CBW76311.1
Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family.
     
 0.930
tgt
Queuine tRNA-ribosyltransferase (EC 2.4.2.29); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ri [...]
 
 
    0.908
surE
Acid phosphatase surE (EC 3.1.3.2); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
   
 
 0.908
CBW75599.1
Folylpolyglutamate synthase (EC 6.3.2.17) / Dihydrofolate synthase (EC 6.3.2.12); COG: Folylpolyglutamate synthase; Pfam: Mur ligase middle domain::PF08245; Belongs to the folylpolyglutamate synthase family.
     
 0.860
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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