STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBW76034.14-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262); COG: Pyridoxal phosphate biosynthesis protein; Pfam: Pyridoxal phosphate biosynthetic protein PdxA::PF04166; Belongs to the PdxA family. (266 aa)    
Predicted Functional Partners:
CBW76033.1
4-hydroxythreonine-4-phosphate dehydrogenase (EC 1.1.1.262); COG: Pyridoxal phosphate biosynthesis protein; Belongs to the PdxA family.
     0.994
serC
Phosphoserine aminotransferase (EC 2.6.1.52); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.
     
 0.908
CBW74929.1
Threonine synthase (EC 4.2.3.1); COG: Threonine synthase; Pfam: Pyridoxal-phosphate dependent enzyme::PF00291.
    
  0.900
rsmA
Dimethyladenosine transferase (EC 2.1.1.-); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.889
gyrB
DNA gyrase subunit B (EC 5.99.1.3); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent [...]
 
      0.788
pdxJ
Pyridoxal phosphate biosynthetic protein pdxJ; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
 
  
 0.781
surA
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.
  
  
 0.772
lptD
Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.
  
    0.748
CBW74267.1
Dihydrofolate reductase (EC 1.5.1.3); COG: Dihydrofolate reductase; Pfam: Dihydrofolate reductase::PF00186; Belongs to the dihydrofolate reductase family.
    
 0.655
CBW76037.1
7.5 kDa CHLOROSOME PROTEIN; COG: Predicted phosphotransferase related to Ser/Thr protein kinases.
       0.561
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.