STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ruvAHolliday junction DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (193 aa)    
Predicted Functional Partners:
ruvB
Holliday junction DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
 
 
 0.999
ruvC
Crossover junction endodeoxyribonuclease ruvC (EC 3.1.22.4); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
 
 
 0.983
CBW75710.1
Hypothetical cytosolic protein; COG: Uncharacterized conserved protein; Pfam: Domain of unknown function DUF28::PF01709.
    
 0.729
CBW76046.1
Unnamed protein product.
       0.701
CBW76077.1
dATP pyrophosphohydrolase (EC 3.6.1.-); COG: NTP pyrophosphohydrolases including oxidative damage repair enzymes; Pfam: NUDIX domain::PF00293.
     0.696
aspS
Aspartyl-tRNA synthetase (EC 6.1.1.12); Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
     0.694
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase (EC 5.-.-.-); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
  
    0.598
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) / IMP cyclohydrolase (EC 3.5.4.10); COG: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); Pfam: AICARFT/IMPCHase bienzyme::PF01808<br>MGS-like domain::PF02142.
     
 0.576
ligA
NAD-dependent DNA ligase (EC 6.5.1.2); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily.
  
   
 0.557
xseA
Exodeoxyribonuclease VII large subunit (EC 3.1.11.6); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
 
   
 0.554
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.