STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ilvCKetol-acid reductoisomerase (EC 1.1.1.86) / 2-dehydropantoate 2-reductase (EC 1.1.1.169); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)    
Predicted Functional Partners:
CBW75693.1
Acetolactate synthase small subunit (EC 2.2.1.6); COG: Acetolactate synthase, small (regulatory) subunit; Pfam: ACT domain::PF01842.
 
 
 0.999
CBW75694.1
Acetolactate synthase large subunit (EC 2.2.1.6); COG: Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Pfam: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain::PF02775<br>Thiamine pyrophosphate enzyme, central domain::PF00205<br>Thiamine pyrophosphate enzyme, N-terminal TPP binding domain::PF02776.
 
 
 0.996
leuC
3-isopropylmalate dehydratase large subunit (EC 4.2.1.33); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
  
 0.985
CBW74119.1
Dihydroxy-acid dehydratase (EC 4.2.1.9); COG: Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.979
CBW74118.1
Dihydroxy-acid dehydratase (EC 4.2.1.9); COG: Dihydroxyacid dehydratase/phosphogluconate dehydratase; Pfam: Dehydratase family::PF00920; Belongs to the IlvD/Edd family.
 
 
 0.978
leuD
3-isopropylmalate dehydratase small subunit (EC 4.2.1.33); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
  
 0.951
leuB
3-isopropylmalate dehydrogenase (EC 1.1.1.85); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
  
 0.911
leuA-2
2-isopropylmalate synthase (EC 2.3.3.13); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
  
 0.755
CBW74610.1
Glutamate synthase [NADPH] large chain (EC 1.4.1.13); COG: Glutamate synthase domain 1; Pfam: Glutamine amidotransferases class-II::PF00310<br>GXGXG motif::PF01493<br>Glutamate synthase central domain::PF04898<br>Conserved region in glutamate synthase::PF01645.
  
  
 0.712
CBW74929.1
Threonine synthase (EC 4.2.3.1); COG: Threonine synthase; Pfam: Pyridoxal-phosphate dependent enzyme::PF00291.
  
  
 0.707
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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