STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
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[Homology]
Score
CBW76311.1Methylenetetrahydrofolate reductase (EC 1.5.1.20); COG: 5,10-methylenetetrahydrofolate reductase; Pfam: Methylenetetrahydrofolate reductase::PF02219; Belongs to the methylenetetrahydrofolate reductase family. (340 aa)    
Predicted Functional Partners:
CBW76224.1
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) cobalamin-binding subunit; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 
 0.975
CBW76223.1
5-methyltetrahydrofolate--homocysteine methyltransferase (EC 2.1.1.13) homocysteine-binding subunit; COG: Methionine synthase I (cobalamin-dependent), methyltransferase domain; Pfam: Homocysteine S-methyltransferase::PF02574.
 
 
 0.974
glyA
Serine hydroxymethyltransferase (EC 2.1.2.1); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.947
gcvT
Aminomethyltransferase (EC 2.1.2.10); The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.938
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.937
thyA
Thymidylate synthase (EC 2.1.1.45); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.930
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase (EC 2.1.1.14); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
 
 0.921
CBW76312.1
Integral membrane protein; COG: Predicted membrane protein; Pfam: Membrane protein of unknown function::PF04020.
  
    0.797
ahcY
Adenosylhomocysteinase (EC 3.3.1.1); May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
  
 0.746
metK
S-adenosylmethionine synthetase (EC 2.5.1.6); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.720
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
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