STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CBW73876.1Ribonucleoside-diphosphate reductase alpha chain (EC 1.17.4.1); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (1046 aa)    
Predicted Functional Partners:
CBW73878.1
Ribonucleoside-diphosphate reductase beta chain (EC 1.17.4.1); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
 0.999
queE
Queuosine biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
  
 
 0.965
tmk
Thymidylate kinase (EC 2.7.4.9); Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.952
adk
Adenylate kinase (EC 2.7.4.3) / Nucleoside-diphosphate kinase (EC 2.7.4.6); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.938
ndk
Nucleoside diphosphate kinase (EC 2.7.4.6); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
 0.937
gmk
Guanylate kinase (EC 2.7.4.8); Essential for recycling GMP and indirectly, cGMP.
     
 0.934
cmk
Cytidylate kinase (EC 2.7.4.14); COG: Cytidylate kinase; Pfam: Cytidylate kinase::PF02224.
  
 
 0.920
CBW75878.1
Unnamed protein product.
   
 0.916
CBW75886.1
Transcriptional regulator, algH; COG: Putative transcriptional regulator; Pfam: Uncharacterized ACR, COG1678::PF02622; Belongs to the UPF0301 (AlgH) family.
   
 0.916
CBW74184.1
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
 0.905
Your Current Organism:
Paraburkholderia rhizoxinica
NCBI taxonomy Id: 882378
Other names: Burkholderia rhizoxinica HKI 454, P. rhizoxinica HKI 454, Paraburkholderia rhizoxinica HKI 454
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.