| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DvMF_0056 | DvMF_0060 | DvMF_0056 | DvMF_0060 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | 0.469 |
| DvMF_0056 | dacA | DvMF_0056 | DvMF_0057 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.828 |
| DvMF_0056 | ftsH | DvMF_0056 | DvMF_0055 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.895 |
| DvMF_0056 | glmM | DvMF_0056 | DvMF_0059 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.811 |
| DvMF_0060 | DvMF_0056 | DvMF_0060 | DvMF_0056 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.469 |
| DvMF_0060 | DvMF_2691 | DvMF_0060 | DvMF_2691 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | 0.924 |
| DvMF_0060 | dacA | DvMF_0060 | DvMF_0057 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | Protein of unknown function DUF147; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. | 0.470 |
| DvMF_0060 | ftsH | DvMF_0060 | DvMF_0055 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.534 |
| DvMF_0060 | glmM | DvMF_0060 | DvMF_0059 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.738 |
| DvMF_0060 | glmS | DvMF_0060 | DvMF_1706 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | Glucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.446 |
| DvMF_0060 | glmU | DvMF_0060 | DvMF_1181 | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.906 |
| DvMF_0256 | DvMF_2691 | DvMF_0256 | DvMF_2691 | PFAM: AMP-dependent synthetase and ligase; KEGG: dde:Dde_1725 long-chain-fatty-acid--CoA ligase. | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | 0.444 |
| DvMF_0256 | glmM | DvMF_0256 | DvMF_0059 | PFAM: AMP-dependent synthetase and ligase; KEGG: dde:Dde_1725 long-chain-fatty-acid--CoA ligase. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.689 |
| DvMF_2357 | DvMF_2691 | DvMF_2357 | DvMF_2691 | PFAM: AMP-dependent synthetase and ligase; KEGG: dde:Dde_0557 acyl-CoA synthetase. | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | 0.444 |
| DvMF_2357 | glmM | DvMF_2357 | DvMF_0059 | PFAM: AMP-dependent synthetase and ligase; KEGG: dde:Dde_0557 acyl-CoA synthetase. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.689 |
| DvMF_2691 | DvMF_0060 | DvMF_2691 | DvMF_0060 | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: dde:Dde_1518 UDP-glucose pyrophosphorylase. | 0.924 |
| DvMF_2691 | DvMF_0256 | DvMF_2691 | DvMF_0256 | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | PFAM: AMP-dependent synthetase and ligase; KEGG: dde:Dde_1725 long-chain-fatty-acid--CoA ligase. | 0.444 |
| DvMF_2691 | DvMF_2357 | DvMF_2691 | DvMF_2357 | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | PFAM: AMP-dependent synthetase and ligase; KEGG: dde:Dde_0557 acyl-CoA synthetase. | 0.444 |
| DvMF_2691 | glmM | DvMF_2691 | DvMF_0059 | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.707 |
| DvMF_2691 | glmS | DvMF_2691 | DvMF_1706 | KEGG: dde:Dde_2931 mannose-1-phosphate guanylyltransferase (GDP); TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein. | Glucosamine/fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.930 |