STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPAGlycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (443 aa)    
Predicted Functional Partners:
DvMF_0223
Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2.
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.999
DvMF_0341
TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dde:Dde_1996 glycine cleavage system T protein.
 
 0.999
DvMF_0222
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase.
 
 
 0.990
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.971
DvMF_0572
Threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: dde:Dde_1657 L-threonine aldolase.
    
 0.926
DvMF_0434
KEGG: dde:Dde_1764 phosphoribosylformylglycinamidine synthase I.
  
 
  0.862
DvMF_2099
TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: dde:Dde_0104 L-glutamine synthetase.
   
 
 0.834
DvMF_2388
Ferredoxin-dependent glutamate synthase; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; ferredoxin-dependent glutamate synthase; KEGG: sfu:Sfum_1724 ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family.
   
 
 0.834
DvMF_1346
PFAM: Glu/Leu/Phe/Val dehydrogenase; KEGG: dde:Dde_1382 glutamate dehydrogenase (NAD).
   
 
 0.829
Your Current Organism:
Desulfovibrio vulgaris Miyazaki
NCBI taxonomy Id: 883
Other names: D. vulgaris str. 'Miyazaki F', Desulfovibrio vulgaris (strain Miyazaki), Desulfovibrio vulgaris str. 'Miyazaki F'
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