node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DvMF_0138 | DvMF_0365 | DvMF_0138 | DvMF_0365 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | 0.818 |
DvMF_0138 | DvMF_0366 | DvMF_0138 | DvMF_0366 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | PFAM: protein of unknown function DUF374; KEGG: dde:Dde_1961 hypothetical protein. | 0.433 |
DvMF_0138 | DvMF_2274 | DvMF_0138 | DvMF_2274 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.853 |
DvMF_0138 | DvMF_2308 | DvMF_0138 | DvMF_2308 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | KEGG: dde:Dde_0335 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS); Belongs to the SIS family. GutQ/KpsF subfamily. | 0.884 |
DvMF_0138 | kdsA | DvMF_0138 | DvMF_0432 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: dde:Dde_1766 2-dehydro-3-deoxyphosphooctonate aldolase. | 0.841 |
DvMF_0138 | lpxA | DvMF_0138 | DvMF_3001 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.972 |
DvMF_0138 | lpxC | DvMF_0138 | DvMF_1446 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.870 |
DvMF_0138 | lpxD | DvMF_0138 | DvMF_2999 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.989 |
DvMF_0138 | lpxK | DvMF_0138 | DvMF_0926 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.986 |
DvMF_0138 | msbA | DvMF_0138 | DvMF_0367 | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | ABC transporter related; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.456 |
DvMF_0365 | DvMF_0138 | DvMF_0365 | DvMF_0138 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.818 |
DvMF_0365 | DvMF_0366 | DvMF_0365 | DvMF_0366 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | PFAM: protein of unknown function DUF374; KEGG: dde:Dde_1961 hypothetical protein. | 0.990 |
DvMF_0365 | DvMF_2274 | DvMF_0365 | DvMF_2274 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | Three-deoxy-D-manno-octulosonic-acid transferase domain protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.974 |
DvMF_0365 | DvMF_2308 | DvMF_0365 | DvMF_2308 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | KEGG: dde:Dde_0335 KpsF/GutQ family protein; TIGRFAM: KpsF/GutQ family protein; PFAM: CBS domain containing protein; sugar isomerase (SIS); Belongs to the SIS family. GutQ/KpsF subfamily. | 0.759 |
DvMF_0365 | kdsA | DvMF_0365 | DvMF_0432 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: dde:Dde_1766 2-dehydro-3-deoxyphosphooctonate aldolase. | 0.635 |
DvMF_0365 | lpxA | DvMF_0365 | DvMF_3001 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.797 |
DvMF_0365 | lpxC | DvMF_0365 | DvMF_1446 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.779 |
DvMF_0365 | lpxD | DvMF_0365 | DvMF_2999 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.783 |
DvMF_0365 | lpxK | DvMF_0365 | DvMF_0926 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.816 |
DvMF_0365 | msbA | DvMF_0365 | DvMF_0367 | PFAM: lipid A biosynthesis acyltransferase; KEGG: lip:LI0871 acyltransferase, HtrB/MsbB family. | ABC transporter related; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.748 |