node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DvMF_0452 | DvMF_0453 | DvMF_0452 | DvMF_0453 | KEGG: dde:Dde_2094 hypothetical protein. | PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein; KEGG: dde:Dde_2095 TrkA family potassium uptake protein. | 0.780 |
DvMF_0452 | ligA | DvMF_0452 | DvMF_0451 | KEGG: dde:Dde_2094 hypothetical protein. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.790 |
DvMF_0452 | uvrB | DvMF_0452 | DvMF_0454 | KEGG: dde:Dde_2094 hypothetical protein. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.479 |
DvMF_0453 | DvMF_0452 | DvMF_0453 | DvMF_0452 | PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein; KEGG: dde:Dde_2095 TrkA family potassium uptake protein. | KEGG: dde:Dde_2094 hypothetical protein. | 0.780 |
DvMF_0453 | DvMF_1860 | DvMF_0453 | DvMF_1860 | PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein; KEGG: dde:Dde_2095 TrkA family potassium uptake protein. | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate:ferredoxin (flavodoxin) oxidoreductase; KEGG: dde:Dde_3237 pyruvate:ferredoxin (flavodoxin) oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | 0.511 |
DvMF_0453 | ligA | DvMF_0453 | DvMF_0451 | PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein; KEGG: dde:Dde_2095 TrkA family potassium uptake protein. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.806 |
DvMF_0453 | uvrB | DvMF_0453 | DvMF_0454 | PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein; KEGG: dde:Dde_2095 TrkA family potassium uptake protein. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.529 |
DvMF_1758 | ligA | DvMF_1758 | DvMF_0451 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3499 ATP-dependent DNA helicase UvrD. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.733 |
DvMF_1758 | polA | DvMF_1758 | DvMF_1713 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3499 ATP-dependent DNA helicase UvrD. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.826 |
DvMF_1758 | topA | DvMF_1758 | DvMF_2069 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3499 ATP-dependent DNA helicase UvrD. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.860 |
DvMF_1758 | uvrB | DvMF_1758 | DvMF_0454 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3499 ATP-dependent DNA helicase UvrD. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.797 |
DvMF_1860 | DvMF_0453 | DvMF_1860 | DvMF_0453 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate:ferredoxin (flavodoxin) oxidoreductase; KEGG: dde:Dde_3237 pyruvate:ferredoxin (flavodoxin) oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein; KEGG: dde:Dde_2095 TrkA family potassium uptake protein. | 0.511 |
DvMF_1860 | leuS | DvMF_1860 | DvMF_3090 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate:ferredoxin (flavodoxin) oxidoreductase; KEGG: dde:Dde_3237 pyruvate:ferredoxin (flavodoxin) oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | TIGRFAM: leucyl-tRNA synthetase; KEGG: dde:Dde_2439 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.732 |
DvMF_1860 | ligA | DvMF_1860 | DvMF_0451 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate:ferredoxin (flavodoxin) oxidoreductase; KEGG: dde:Dde_3237 pyruvate:ferredoxin (flavodoxin) oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.739 |
DvMF_1860 | polA | DvMF_1860 | DvMF_1713 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate:ferredoxin (flavodoxin) oxidoreductase; KEGG: dde:Dde_3237 pyruvate:ferredoxin (flavodoxin) oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.448 |
DvMF_1860 | topA | DvMF_1860 | DvMF_2069 | PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; pyruvate:ferredoxin (flavodoxin) oxidoreductase; KEGG: dde:Dde_3237 pyruvate:ferredoxin (flavodoxin) oxidoreductase; Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.964 |
DvMF_1967 | ligA | DvMF_1967 | DvMF_0451 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3571 ATP-dependent DNA helicase UvrD. | DNA ligase, NAD-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.702 |
DvMF_1967 | polA | DvMF_1967 | DvMF_1713 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3571 ATP-dependent DNA helicase UvrD. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.779 |
DvMF_1967 | topA | DvMF_1967 | DvMF_2069 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3571 ATP-dependent DNA helicase UvrD. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.788 |
DvMF_1967 | uvrB | DvMF_1967 | DvMF_0454 | PFAM: UvrD/REP helicase; KEGG: dde:Dde_3571 ATP-dependent DNA helicase UvrD. | Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.830 |