Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DvMF_1644KEGG: pfl:PFL_3748 hypothetical protein. (262 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.990
DvMF_1758
PFAM: UvrD/REP helicase; KEGG: dde:Dde_3499 ATP-dependent DNA helicase UvrD.
  
 0.986
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.979
DvMF_3176
KEGG: dde:Dde_1318 DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: TOPRIM domain protein; DNA topoisomerase type IA central domain protein; SMART: DNA topoisomerase I ATP-binding; DNA topoisomerase I DNA-binding; Toprim sub domain protein.
  
 0.974
recD2
Helicase, RecD/TraA family; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily.
  
 0.972
DvMF_0339
PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: dde:Dde_1998 recombination factor protein RarA.
  
 0.971
DvMF_0813
TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n; KEGG: dde:Dde_1545 single-strand binding protein.
   
 0.970
DvMF_1967
PFAM: UvrD/REP helicase; KEGG: dde:Dde_3571 ATP-dependent DNA helicase UvrD.
  
 0.970
DvMF_2082
KEGG: dde:Dde_0002 DNA polymerase III, beta subunit; TIGRFAM: DNA polymerase III, beta subunit; PFAM: DNA polymerase III beta chain.
  
 0.968
DvMF_1938
KEGG: dde:Dde_0177 DNA polymerase III, delta prime subunit, putative.
  
 0.954
Your Current Organism:
Desulfovibrio vulgaris Miyazaki
NCBI taxonomy Id: 883
Other names: D. vulgaris str. 'Miyazaki F', Desulfovibrio vulgaris (strain Miyazaki), Desulfovibrio vulgaris str. 'Miyazaki F'
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