Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DvMF_2902Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: dde:Dde_2576 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (333 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.997
DvMF_2767
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: dde:Dde_2837 uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferase.
 
 
 0.994
hemL
TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: dde:Dde_3180 glutamate-1-semialdehyde 2,1-aminomutase.
 
 
 0.993
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.877
DvMF_3095
TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase.
     
 0.644
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.633
DvMF_2901
PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dde:Dde_2577 elongator protein 3/MiaB/NifB.
  
  
 0.622
DvMF_0298
TIGRFAM: siroheme synthase; KEGG: dde:Dde_2023 precorrin-2 dehydrogenase.
 
   
 0.605
DvMF_2900
KEGG: dde:Dde_2578 AsnC family transcriptional regulator.
     
 0.602
DvMF_1928
PFAM: FAD dependent oxidoreductase; KEGG: dde:Dde_0216 UDP-galactopyranose mutase.
  
  
 0.597
Your Current Organism:
Desulfovibrio vulgaris Miyazaki
NCBI taxonomy Id: 883
Other names: D. vulgaris str. 'Miyazaki F', Desulfovibrio vulgaris (strain Miyazaki), Desulfovibrio vulgaris str. 'Miyazaki F'
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