| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DvMF_0209 | DvMF_1862 | DvMF_0209 | DvMF_1862 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: dde:Dde_1681 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: FAD linked oxidase domain protein; KEGG: dde:Dde_3239 glycolate oxidase, subunit GlcD. | 0.921 |
| DvMF_0209 | DvMF_2875 | DvMF_0209 | DvMF_2875 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: dde:Dde_1681 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | PFAM: FAD linked oxidase domain protein; KEGG: dde:Dde_1087 glycolate oxidase, subunit GlcD, putative. | 0.930 |
| DvMF_0209 | DvMF_3003 | DvMF_0209 | DvMF_3003 | PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: dde:Dde_1681 D-isomer specific 2-hydroxyacid dehydrogenase family protein. | Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: rci:RRC4 putative aminotransferase. | 0.906 |
| DvMF_0222 | DvMF_0223 | DvMF_0222 | DvMF_0223 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | 0.997 |
| DvMF_0222 | DvMF_0341 | DvMF_0222 | DvMF_0341 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dde:Dde_1996 glycine cleavage system T protein. | 0.990 |
| DvMF_0222 | DvMF_2099 | DvMF_0222 | DvMF_2099 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: dde:Dde_0104 L-glutamine synthetase. | 0.843 |
| DvMF_0222 | DvMF_3003 | DvMF_0222 | DvMF_3003 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: rci:RRC4 putative aminotransferase. | 0.900 |
| DvMF_0222 | gcvH | DvMF_0222 | DvMF_0225 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.998 |
| DvMF_0222 | gcvPA | DvMF_0222 | DvMF_0224 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.996 |
| DvMF_0222 | glyA | DvMF_0222 | DvMF_3097 | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
| DvMF_0223 | DvMF_0222 | DvMF_0223 | DvMF_0222 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | 0.997 |
| DvMF_0223 | DvMF_0341 | DvMF_0223 | DvMF_0341 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dde:Dde_1996 glycine cleavage system T protein. | 0.999 |
| DvMF_0223 | DvMF_2099 | DvMF_0223 | DvMF_2099 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: dde:Dde_0104 L-glutamine synthetase. | 0.829 |
| DvMF_0223 | DvMF_3003 | DvMF_0223 | DvMF_3003 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: rci:RRC4 putative aminotransferase. | 0.903 |
| DvMF_0223 | gcvH | DvMF_0223 | DvMF_0225 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
| DvMF_0223 | gcvPA | DvMF_0223 | DvMF_0224 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.999 |
| DvMF_0223 | glyA | DvMF_0223 | DvMF_3097 | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.995 |
| DvMF_0341 | DvMF_0222 | DvMF_0341 | DvMF_0222 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dde:Dde_1996 glycine cleavage system T protein. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: dde:Dde_1690 dihydrolipoamide dehydrogenase. | 0.990 |
| DvMF_0341 | DvMF_0223 | DvMF_0341 | DvMF_0223 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dde:Dde_1996 glycine cleavage system T protein. | Glycine dehydrogenase (decarboxylating); PFAM: glycine cleavage system P-protein; KEGG: dde:Dde_1691 glycine dehydrogenase subunit 2. | 0.999 |
| DvMF_0341 | DvMF_2099 | DvMF_0341 | DvMF_2099 | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: dde:Dde_1996 glycine cleavage system T protein. | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: dde:Dde_0104 L-glutamine synthetase. | 0.836 |