| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DvMF_1762 | DvMF_3094 | DvMF_1762 | DvMF_3094 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: dde:Dde_3505 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | 0.940 |
| DvMF_1762 | DvMF_3095 | DvMF_1762 | DvMF_3095 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: dde:Dde_3505 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | 0.679 |
| DvMF_1762 | ribBA | DvMF_1762 | DvMF_3093 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: dde:Dde_3505 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.635 |
| DvMF_1762 | ribH | DvMF_1762 | DvMF_3092 | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: dde:Dde_3505 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.697 |
| DvMF_3094 | DvMF_1762 | DvMF_3094 | DvMF_1762 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: dde:Dde_3505 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | 0.940 |
| DvMF_3094 | DvMF_3095 | DvMF_3094 | DvMF_3095 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | 0.999 |
| DvMF_3094 | DvMF_3096 | DvMF_3094 | DvMF_3096 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dde:Dde_2433 cytidine/deoxycytidylate deaminase family protein. | 0.727 |
| DvMF_3094 | DvMF_3100 | DvMF_3094 | DvMF_3100 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | 3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.501 |
| DvMF_3094 | glyA | DvMF_3094 | DvMF_3097 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.505 |
| DvMF_3094 | leuS | DvMF_3094 | DvMF_3090 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | TIGRFAM: leucyl-tRNA synthetase; KEGG: dde:Dde_2439 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.492 |
| DvMF_3094 | nusB | DvMF_3094 | DvMF_3091 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.545 |
| DvMF_3094 | ribB | DvMF_3094 | DvMF_2680 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. | 0.995 |
| DvMF_3094 | ribBA | DvMF_3094 | DvMF_3093 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
| DvMF_3094 | ribH | DvMF_3094 | DvMF_3092 | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| DvMF_3095 | DvMF_1762 | DvMF_3095 | DvMF_1762 | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; KEGG: dde:Dde_3505 riboflavin kinase / FMN adenylyltransferase; Belongs to the ribF family. | 0.679 |
| DvMF_3095 | DvMF_3094 | DvMF_3095 | DvMF_3094 | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: dde:Dde_2435 riboflavin synthase subunit alpha. | 0.999 |
| DvMF_3095 | DvMF_3096 | DvMF_3095 | DvMF_3096 | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: dde:Dde_2433 cytidine/deoxycytidylate deaminase family protein. | 0.860 |
| DvMF_3095 | glyA | DvMF_3095 | DvMF_3097 | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.586 |
| DvMF_3095 | leuS | DvMF_3095 | DvMF_3090 | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | TIGRFAM: leucyl-tRNA synthetase; KEGG: dde:Dde_2439 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.432 |
| DvMF_3095 | nusB | DvMF_3095 | DvMF_3091 | TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase zinc-binding; bifunctional deaminase-reductase domain protein; KEGG: dde:Dde_2434 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase. | NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. | 0.848 |